A Resource for magnetic resonance and optical imaging

描述(由申请人提供)： 该区域资源的任务是为生物医学研究开发创新的磁共振(MR)和光学技术。这些技术是由生物医学领域的基础和临床研究合作者推动的，不仅是为了解决特定的临床问题，而且是为了进一步了解体内生物系统的生物物理、生理、结构和功能特性。与我们的合作者一起，我们开发了以下四个广泛的核心研究领域：第一个核心领域涉及开发新的磁共振技术，用于研究软骨、脑和肿瘤的结构、生化和代谢方面，并直接应用于关节炎、中风和阿尔茨海默病。CORE I还开发了新的图像重建策略，以量化乳房和其他组织中的高时间对比剂动力学。在第二个核心中，我们介绍了我们在高场和儿科成像中改进的定量灌注的发展以及同时进行血流和葡萄糖代谢成像的方法的研究。它还开发了将功能磁共振成像与光学成像相关联的策略。核心三分项目涉及超极化气体的磁共振和开发研究肺部和鼻窦疾病的综合方法。第四个也是最后一个核心重点是结合光学和磁共振成像技术，开发用于代谢成像的双光子光学成像方法，以及用于神经生理学和乳腺癌研究的扩散断层扫描的图像重建策略。这些核心开发的技术将推动20个合作项目，研究各种正常和病理生理组织，并根据需要支持服务项目。该资源提供的服务包括1.5T、2T、3T研究磁铁系统、4.7T动物磁铁、线圈设施、光学成像设备、极化气体成像装置、磁力锻炼设备以及由该资源开发的计算机软件。该资源还维持着一个广泛的培训和传播方案，包括研讨会、MR课程、讲习班、培训讲座、MR和光学方法的实用培训、通讯、在国家和国际会议上的陈述，以及一个资源网站，该网站提供对资源开发的所有出版物和软件包的访问。在宾夕法尼亚大学放射科的支持下，研究资源仍然致力于基础医学和临床医学的知识交流和跨学科追求。

DESCRIPTION (provided by applicant): The mission of the regional resource is to develop innovative magnetic resonance (MR) and optical technologies for biomedical research. These technologies are driven both by basic and clinical research collaborators in the biomedical field to not only address specific clinical problems but also to further fundamental understanding of biophysical, physiological, structural, and functional properties of biological systems in vivo. In conjunction with our collaborators, we have developed the following four broad areas of core research: The first core deals with the development of novel MR techniques for studying the structural, biochemical and metabolic aspects of cartilage, brain, and tumors, with direct application to arthritis, stroke, and Alzheimer's disease. Core I also develops novel image reconstruction strategies to quantify high temporal contrast agent dynamics in breast and other tissues. In the second core, we present our research on the development of improved, quantitative perfusion at high fields and in pediatric imaging and methods for concurrent imaging of blood flow and glucose metabolism. It also develops strategies for correlation of fMRI with optical imaging. Core III subprojects deal with MR of hyperpolarized gases and development of a comprehensive approach for the study of pulmonary and sinuses diseases. The fourth and final core focuses on combining optical and MR imaging techniques, development of methods of two photon optical imaging for metabolic imaging and image reconstruction strategies in diffusion tomography for the study of neurophysiology, and breast cancer. Technology developed by these cores will drive twenty collaborative projects in the study of various normal and pathophysiological tissues and support service projects as required. Service provided by the resource includes access to the 1.5T, 2T, 3T research magnet systems, 4.7T animal magnet, coil facility, optical imaging facility, polarized gas imaging set-up, in-magnet exercise devices, and computer software developed by the resource. The resource also maintains an extensive training and dissemination program consisting of seminars, MR courses, workshops, training lectures, practical training in MR and optical methods, and newsletters, presentations at national and international conferences, and a resource web site that provides access to all publications and software packages developed by the resource. The research resource with the auspices of the Radiology department at the University of Pennsylvania remains committed to intellectual interchange and the interdisciplinary pursuit of basic and clinical medicine.