Core--Analytical Chemistry/AMS

分析核心是由三个实验室组成的中央资源，促进现代分析方法的开发和应用，以解决超级基金计划各组成部分遇到的关键问题。第一个实验室是超级基金分析实验室，提供一系列仪器服务，主要依靠质谱和色谱法。第二个是加速器质谱设施，在戴维斯有一个新的样品制备实验室，在LLNL有两台AMS仪器，用于14 C和36 C1作为重同位素的超痕量分析。第三个是分子结构设施（MSF），在蛋白质和核酸化学领域提供收费服务。超级基金分析实验室为小分子和蛋白质分析（与无国界医生合作）提供广泛的分析服务。支持两者的分析能力 蛋白质组学和代谢组学的“组学核心5”位于这里。核心提供步行仪器以及服务和研究合作的项目。它通过开发机器人样品清理程序、免疫亲和色谱法和“阀上实验室”样品制备方法来推进分析技术。它与项目合作，对危险混合物进行生物测定驱动的分馏， 为超级基金科学家提供分析化学方面的教育。LLNL组件提供了对各种先进仪器的访问，但将侧重于加速器质谱（AMS）的亚阿摩尔（即10[-8]）灵敏度，以支持使用14 C和36 C1分析的各种项目。例如，这种技术首次允许在环境现实水平上监测人类对危险化学品的代谢。核心科学家将教育超级基金的研究人员在使用和一系列分析技术的价值。

The Analytical Core is a central resourse composed of three laboratories which facilitate the development and application of modern analytical methods to solve key problems encountered by the components of the Superfund Program. The first laboratory is the Superfund Analytical Laboratory which provides a range of instrument services relying heavily on mass spectrometry and chromatography. The second is the Accelerator Mass Spectrometry Facility with a new sample preparation laboratory in Davis and 2 AMS instruments at LLNL for ultra trace analysis of 14C and 36C1 as heavy isotopes. The third is the Molecular Structure Facility (MSF) which provides service for fee in the area of protein and nucleic acid chemistry. The Superfund Analytical Laboratory provides a wide range of analytical services for both small molecule and (in collaboration with MSF) for protein analysis. The analytical capability supporting both proteomics and metabolomics of the 'omics core 5' is located here. The core provides walk up instrumentation as well as service and research collaboration to the projects. It advances analytical technology for example by developing robotic sample clean up procedures, immunoaffinity chromatography and 'lab on a valve' approaches to sample preparation. It carries out bioassay driven fractionation of hazardous mixtures in collaboration with the projects and provides education for Superfund scientists in analytical chemistry. The LLNL component provides access to a variety of advanced instruments but will focus on the sub attomole (i.e. 10[-8]) sensitivity of Accelerator Mass Spectrometry (AMS) in support of a variety of projects using both 14C and 36C1 analysis. This technique for example for the first time allows monitoring of human metabolism of hazardous chemicals at environmentally realistic levels. Core scentists will educate Superfund researchers in the use and value of a full array of analytical techniques.