Alzheimer's Disease Research Center

描述（由申请人提供）：华盛顿大学（UW）阿尔茨海默病研究中心（ADRC）的总体目标是继续支持和加强互动的多学科中心环境，使正在进行的研究项目和新的研究计划能够解决阿尔茨海默病（AD）和其他神经退行性痴呆症的发病机制、病理生理学和治疗。一个由基础和临床研究人员、医疗保健专业人员和行政人员组成的跨学科合作团队在华盛顿大学联合起来，支持和开展一系列富有成效的痴呆症项目。主要的重点是针对AD和其他痴呆症的遗传学的项目：其他研究工作已经解决了AD和正常衰老的神经内分泌学和神经化学，以及AD的药理学和行为治疗。ADRC支持和促进ADRC内部的生产性研究，在更大的UW研究界和全国通过直接合作和正式的多中心计划，如国家阿尔茨海默氏症协调中心（NACC），阿尔茨海默氏症合作研究（ADCS），新整合的UW ADRC/俄勒冈州健康与科学大学ADC神经病理学核心，以及晚发性家族性AD倡议的多站点NIA遗传学。ADRC创造了一个职业发展环境，研究员和初级教师在跨学科AD研究环境中获得研究和临床技能和工作经验。上一个资助期的成就涵盖了对AD知识的广泛的基础，临床和行为贡献。目前的申请要求继续七个ADRC核心，并提出了三个研究项目。两个项目继续我们富有成效的纲领性主题的遗传学的AD：第一个使用数量性状连锁分析，以找到易感基因晚发性AD;第二个将确定修改器的发病年龄早老素-2突变引起的AD。第三个项目将利用UW ADRC CSF和脑库，并应用蛋白质组学来解决痴呆诊断和监测疾病进展的生物标志物的需求。

DESCRIPTION (provided by applicant): The overall goal of the University of Washington (UW) Alzheimer's Disease Research Center (ADRC) is to continue to support and enhance an interactive multidisciplinary center milieu that enables ongoing research projects and new research initiatives addressing the pathogenesis, pathophysiology, and treatment of Alzheimer's disease (AD) and other neurodegenerative dementing disorders. An interdisciplinary collaborative team of basic and clinical investigators, health care professionals, and administrative personnel has coalesced at the UW to support and carry out an array of productive dementia programs. Primary emphasis has been directed at projects addressing the genetics of AD and other dementing disorders: other research efforts have addressed neuroendocrinology and neurochemistry of AD and normal aging, and both pharmacologic and behavioral treatments of AD. The ADRC supports and fosters productive research within the ADRC, in the greater UW research community and nationally through direct collaborations and formal multi-center programs such as the National Alzheimer's Coordinating Center (NACC), the Alzheimer's Disease Cooperative Study (ADCS), the newly integrated UW ADRC/Oregon Health and Science University ADC Neuropathology Core, and the multisite NIA genetics of late-onset familial AD initiative. The ADRC has created a career development environment in which fellows and junior faculty acquire research and clinical skills and experience working in an interdisciplinary AD research setting. Accomplishments of the previous funding period have covered a broad spectrum of basic, clinical and behavioral contributions to knowledge about AD. The current application requests continuation of seven ADRC cores and proposes three research projects. Two projects continue our productive programmatic theme of the genetics of AD: the first uses quantitative trait linkage analysis to find susceptibility genes for late onset AD; the second will identify modifiers of age of onset of presenilin-2 mutation caused AD. The third project will utilize the UW ADRC CSF and brain banks and apply proteomics to address the need for biomarkers for dementia diagnosis and monitoring disease progression.