Gene variants related to bone density and fracture.

骨密度和骨质疏松症有遗传因素。识别与骨密度有关的基因可能会在控制骨质疏松症方面取得进展。我们已经确定了一种与骨密度相关的变异，该变异与足够高的骨密度有关，足以保护个人免受科尔骨折的四倍保护，科尔骨折是女性常见的手腕骨折。此外，一些髋部骨折或骨密度低的人，也有这种基因的突变。该基因是构成骨骼的细胞的主调节器：这给了人们希望，通过这个主调节器改变骨形成是可能的。

Bone density and osteoporosis have a genetic component. Identifying genes that are involved in determining bone density may permit advances in controlling osteoporosis. We have identified a variant that is related to bone density high enough to protect individuals four fold against Colle's fracture, the common wrist fracture seen in women. In addition, some people with bone fracture at the hip, or low bone density, have mutations in this gene. The gene is a master regulator of the cells that make bone: this gives hope that it may be possible to alter bone formation through this master regulator.