Siemens Symbia T SPECT-CT Scanner

描述（由申请人提供）：该共享仪器提案是为了获取新的西门子Symbia T SPECT-CT系统。我们目前有许多正在进行的研究项目，这些项目将从专用的研究扫描仪中受益匪浅，该扫描仪能够执行单光子发射计算机断层扫描（SPECT），并允许解剖制图和相关，以及功能图像的衰减校正。这种扫描仪不仅将加强目前测量大脑功能各个方面的研究，而且将使我们能够大大扩大这一领域研究项目的数量。此外，拟议的扫描仪在CT扫描仪的质量上比以前有了实质性的改进。这台扫描仪也有几个软件程序，帮助使用和集成SPECT和CT扫描。我们目前正在进行研究，利用脑SPECT成像来测量脑血流量和几种神经递质系统，以研究神经和精神状况以及激活状态。对神经和精神疾病的研究包括与帕金森病和其他运动障碍、可卡因成瘾、抑郁、焦虑和夜食综合征有关的研究。激活研究目前包括对疼痛感知和安慰剂效应的研究。我们的放射化学小组正在不断致力于开发新的放射性药物，这些药物将应用于研究大脑生理学的许多方面。最近的研究包括测量血清素转运体和检测与阿尔茨海默病相关的病理生理变化的示踪剂。所要求的扫描仪对于继续进行这些研究，开发新的放射性药物以及提供有利于包括许多新研究人员的成像环境至关重要。所要求的扫描仪还具有进行全身平面和SPECT成像的能力，这对于新的放射性药物的生物分布研究以及心脏病学，肿瘤学和传染病的研究是必要的。总的来说，这种扫描仪将成为我们目前和未来研究项目的主要工具，重点是大脑SPECT成像，但也有可能包括许多其他类型的研究。

DESCRIPTION (provided by applicant): This shared instrumentation proposal is for the acquisition of a new Siemens Symbia T SPECT-CT system. We currently have a number of ongoing research projects that would benefit substantially from a dedicated research scanner that had the capability to perform single photon emission computed tomography (SPECT) as well as allow for anatomical mapping and correlation, and attenuation correction of the functional images. Such a scanner will not only enhance the present studies that measure various aspects of cerebral function, but will allow us to greatly expand the number of types of research projects in this area. Furthermore, the proposed scanner provides substantial improvements in the quality of the CT scanner than previously available. This scanner also has several software programs that aid in the use and integration of the SPECT and CT scans. We currently perform studies measuring cerebral blood flow and several neurotransmitter systems utilizing brain SPECT imaging to study neurological and psychiatric conditions as well as activation states. Studies of neurological and psychiatric conditions include those related to Parkinson's disease and other movement disorders, cocaine addiction, depression, anxiety, and night eating syndrome. Activation studies currently include the study of pain perception and the placebo effect. Our radiochemistry group is continually working on developing new radiopharmaceuticals that will have applications for studying many aspects of cerebral physiology. The most recent include tracers to measure the serotonin transporter and detect pathophysiological changes associated with Alzheimer's disease. The requested scanner is critical for continuing these studies, developing new radiopharmaceuticals, and providing an imaging environment conducive to including many new investigators. The requested scanner also has the ability to perform whole body planar and SPECT imaging which is necessary for biodistribution studies of new radiopharmaceuticals, as well as research studies in cardiology, oncology, and infectious disease. Overall, this scanner will become a major tool for our present and future research programs with a focus on brain SPECT imaging, but also the potential to include many other types of studies.