A7 TESLA MAGNET/UNIVERSITY CHICAGO MRI RESEARCH SCANNER

该子项目是利用由NIH/NCRR资助的共享仪器补助金提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是资助机构，不一定是研究者的机构。描述（由申请人提供）：这是一份重新提交的申请，申请获得用于小孔径MRI扫描仪的新磁铁。我们之前提交的材料要求使用7特斯拉的磁铁——审稿人主要担心的是，与现有的4特斯拉相比，这并不是一个显著的改进。7 .特斯拉磁铁。因此，为了直接回应这个问题，我们现在计划购买9.4特斯拉磁铁。放射科和生物科学司将提供这次采购所需资金的余额。升级后的扫描仪将供生物科学司和物理科学司的大量调查人员使用。主要用户将是由25个RO1或同等资助资助的20名研究人员和2名NSF资助的研究人员。此外，该扫描仪是癌症中心和生物科学部的核心设备，并支持许多试点项目。2002年的一项共享仪器拨款为最先进的成像控制台和新的自屏蔽梯度装置支付了费用。然而，4.7特斯拉的磁铁已经有15年的历史了。2003年夏天，它在没有明显原因的情况下熄灭了。它最终得到了修复，但考虑到它的年龄和不稳定性，人们对它的长期运行存在重大担忧。此外，低磁场强度使得代谢光谱、高分辨率成像和基于局部磁化率梯度提供功能和解剖信息的成像（即BOLD成像和高光谱和空间分辨率成像）变得困难。对小动物、细胞、组织和材料的高分辨率成像的巨大需求证明了对最先进的研究磁铁的需求。新的扫描仪将支持范围广泛的研究项目，从癌症研究到脑功能和解剖学研究。该研究项目是转化性的：由扫描仪支持的基础研究将与人类患者和志愿者的平行研究密切相关。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): This is a resubmission of a proposal to acquire a new magnet for a small bore MRI scanner. Our previous submission requested a 7 Tesla magnet - and a primary concern of the reviewers was that this was not a significant improvement over the existing 4. 7 Tesla magnet. Therefore, to respond directly to this concern, we now plan to purchase a 9.4 Tesla magnet. The Department of Radiology and the Biological Sciences Division will provide the balance of funds required for this purchase. The upgraded scanner will be used by a large number of investigators in the Biological Sciences Division as well as the Physical Sciences Division. The primary users will be 20 investigators supported by 25 RO1 or equivalent grants, and 2 NSF funded investigators. In addition, the scanner is a CORE facility for the Cancer Center and the Biological Sciences Division and supports many pilot projects. A Shared Instrumentation Grant in 2002 paid for a state-of-the art imaging console and new self-shielded gradient set. However, the 4.7 Tesla magnet is 15 years old. In the summer of 2003 it quenched without apparent cause. It was eventually repaired but given its age and instability there are significant concerns about its long-term operation. In addition, the low magnetic field strength makes it difficult to perform metabolic spectroscopy, high resolution imaging, and imaging that provides functional and anatomic information based on local magnetic susceptibility gradients (i.e. BOLD imaging and high spectral and spatial resolution imaging). The very large demand for high resolution imaging of small animals, cells, tissues, and materials justifies this request for a state-of-the-art research magnet. The new scanner will support a wide range of research projects ranging from cancer research to studies of brain function and anatomy. The research program is translational: basic research supported by the scanner will be closely linked to parallel studies in human patients and volunteers.