Support for Enhancement Excellence in Research UPR-RP

描述(由申请人提供)：第三份补充申请要求在波多黎各大学里约热内卢分校目前正在进行的SCORE计划中增加两个常规项目。所包括的项目来自生物系。一种是根据第一个分数补充申请的摘要说明中报告的批评意见进行修订的申请(Renaud博士)。另一位来自最近聘用的神经和细胞生物学家，前NIH Marc本科生和博士后，NINDS-NIH博士后研究员(博士维加)。所有这些共同补充了UPR-RP在MBRS计划的支持下已经进行了33年的生物医学研究工作，特别是加强了目前的SCORE计划，该计划包括15个常规项目和3个试点项目(化学项目10个，生物项目6个，数学项目2个)。这两个新项目旨在开展与以下领域相关的竞争性研究：(1)阿片成瘾及其在免疫抑制和传染病传播中的作用(雷诺博士)，以及(2)与细胞内蛋白质聚集有关的神经疾病(维加博士)。 这些调查将由一个正在进行的行政项目以及包括两名实验室技术员和一名博士后助理在内的技术和支助人员进行。这一增强的SCORE计划将为该机构提供一流的研究和开发机会以及完全支持的研究氛围，从而帮助参与该计划的教职员工提高他们的生物医学研究生产率、科学竞争力和同行认可。该项目的研究活动也加强了该机构现有的MARC U*STAR项目。将通过既定的评估计划，每年对每个新项目的具体目标和方案总体目标的进展情况进行评估。

DESCRIPTION (provided by applicant): This third supplemental application requests the addition of two regular projects to the SCORE Program currently active at the University of Puerto Rico, Rio Piedras. The projects included are from the Department of Biology. One is a revised application according to the critiques reported in the summary statement of the first SCORE supplemental application (Dr. Renaud). The other is from a recently hired neuro- and cell biologist, ex-NIH MARC undergraduate and predoctoral and NINDS-NIH postdoctoral fellow (Dr. Vega). All together complement biomedical research efforts at UPR-RP that have been ongoing for over 33 years under the auspices of the MBRS program and specifically, strengthen the present SCORE Program which groups 15 regular and 3 pilot projects (10 in Chemistry, 6 in Biology and 2 in Mathematics). These two new projects aim to conduct competitive research in areas related to (1) opiate addiction and its role in immunosuppression and dissemination of infectious diseases (Dr. Renaud), and (2) to neurological disorders linked to intracellular protein aggregation (Dr. Vega). These investigations are to be sustained by an ongoing administrative project and by technical and support personnel that include two laboratory technicians and one postdoctoral associate. This enhanced SCORE program will provide this institution first-rate research and development opportunities as well as a fully supportive research atmosphere and will thus help the participating faculty to increase their biomedical research productivity, scientific competitiveness and peer recognition. Research activities in the program also enhance the existing MARC U*STAR program at this institution. Progress in the specific aims of each new project and in the overall aims of the program will be evaluated yearly through an established evaluation plan.