Generation of mouse models to study the roles of different Bcl-2 family members in the regulation of apaptosis

程序性细胞死亡或细胞凋亡是清除感染、受损或不需要的细胞所必需的，其被破坏的调节与癌症、自身免疫和退行性疾病有关。Bcl-2家族蛋白是细胞凋亡的关键调控因子。我们建议建立几种小鼠模型，以更好地了解Bcl-2家族不同成员之间的关系，从而控制这一途径以达到治疗目的。

Programmed cell death, or apoptosis, is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. The Bcl-2 family of proteins are key regulators of apoptosis. We propose to generate several mouse models to better understand the relationships between the different members of the Bcl-2 family in an effort to control this pathway for therapeutic purposes.