Engineering Cupriavidus necator for gram-scale production of 1,2-propanediol from CO2

该项目将结合联合收割机代谢工程策略（系统和合成生物学）和发酵过程，筛选和表征适用于拟议途径的不同酶，深入了解代谢，并提出优化工艺，以稳定和连续地从CO2生产克级1，2-PDO。学生将接受代谢途径分析（自养，异养途径），生物信息学的培训，以确定最佳代谢途径，确定要减弱或过度表达的途径或基因，以帮助产品形成。学生将参加研讨会，国家和国际会议，突出结果，与更广泛的科学界互动，并将与诺森比亚大学和宝洁公司的多学科研究团队合作

The project will combine metabolic engineering strategies (systems and synthetic biology) and fermentation process in screening and characterising different enzymes suitable for the proposed pathways, draw insights into the metabolism and propose optimised processes for stable and continuous 1,2-PDO production from CO2 in gram scale. Student will be trained in metabolic pathway analysis (autotrophic, heterotrophic pathways), bioinformatics, to identify optimal metabolic routes, determining pathways or genes to be attenuated or overexpressed aiding the product formation. Student will engage in workshops, national and international conferences highlighting the results, interacting with wider scientific community and will work with multidisciplinary team of researchers at Northumbria University and P&G