Genetic dissection of biofilm development by non-typeable Haemophilus influenzae

细菌病原体非可分型流感嗜血杆菌(NTHi)是囊性纤维化或慢性阻塞性肺疾病(COPD)患者中耳和呼吸道慢性感染的常见原因。这些感染与细菌生物膜有关，这些细菌生物膜对抗生素和免疫防御都具有显著的耐药性。该项目旨在描述NTHi生物膜的发展过程，以便开发新的诊断工具和治疗方法。

The bacterial pathogen non-typeable Haemophilus influenzae (NTHi) is a common cause of chronic infections of the middle ear and of the airways of patients suffering cystic fibrosis, or chronic obstructive pulmonary disease (COPD). These infections are associated with bacterial biofilms that are significantly resistant to both antibiotics and immune defences. This project aims to characterise the process of NTHi biofilm development so that novel diagnostic tools and therapeutics can be developed.