Analytical & Neuropathology

分析和神经病理学核心提供分析神经化学， 病理学、组织、CSF和微透析液库。具体目标是：（1）。 测量硝酸盐/亚硝酸盐作为人类和动物脑外伤后一氧化氮代谢的标志物 在TBI后，对促红细胞生成素（Epo）的施用进行响应。2.）的情况。测量Epo和Epo TBI在人类和动物中的作用。3.）第三章测量微透析液中的炎症生物标志物 和TBI后和对Epo治疗应答的CSF样品。4.）提供神经病理学支持， 实验性TBI的组织病理学分析，包括测量挫伤体积、神经元损失 和抗原表达。5.）为动物提供组织和CSF、血清和微透析液样本库 和创伤性脑损伤的人体组织样本6.）提供花生四烯酸转化为环氧合酶的分析 在实验动物中TBI后P450的产物。正如在程序项目的前几次迭代中， 分析和神经病理学核心与主要科学项目以及其他 丹

The Analytical and Neuropathology Core provides analytical neurochemistry, gross and microscopic pathology, and tissue, CSF and microdialysate banking for the Program Project. The Specific Aims are: 1.) measure nitrate/nitrite as markers of nitric oxide metabolism in humans and animals following traumatic brain injury (TBI) and in response to erythropoietin (Epo) administration following TBI. 2.) measure Epo and Epo receptor following TBI in humans and animals. 3.) measure biomarkers of inflammation in microdialysate and CSF samples following TBI and in response to Epo therapy. 4.) provide neuropathology support for histopathological analysis of experimental TBI including measurement of contusion volumes, neuronal loss, and antigen expression. 5.) provide tissue and CSF, serum, and microdialysate sample banking for animal and human tissue samples from TBI. 6.) provide analysis of arachidonic acid conversion to epoxygenase products by P450 following TBI in experimental animals. As in previous iterations of the Program Project, the Analytical and Neuropathology Core interacts closely with the major scientific projects and with the other cores.