Genetic epidemiology of endometrial cancer: towards understanding aetiology and improving risk prediction.

对数以千计的遗传标记的研究彻底改变了我们对癌症相关基因的理解，并表明一个基因可能与多种癌症相关。我们将进行有史以来最大规模的研究，寻找子宫内膜癌的新基因，子宫内膜癌是最常见的妇科癌症。我们独特的方法将检查基因组中的1100万个标记，其中一些特别是在已知对其他癌症重要的区域。研究结果将用于风险预测模型。

Studies investigating thousands of genetic markers have revolutionised our understanding of genes involved in cancer, and shown that a single gene can be associated with multiple cancers. We will conduct the largest ever study to find new genes for endometrial cancer, the most common gynaecological cancer. Our unique approach will examine >11million markers across the genome, some specifically in regions known to be important for other cancers. Findings will be used for risk prediction models.