Kallikrein gene variants in prostate cancer: in-depth association and functional studies

前列腺癌中激肽释放酶基因变异：深入关联和功能研究

• 批准号: nhmrc : 1013693
• 负责人: Dr Jyotsna Batra
• 金额: $ 20.15万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/kallikrein-gene-variants-functional-studies/109740
• 关键词: Kallikrein; gene; variants; prostate; cancer

The number of men diagnosed with prostate cancer varies substantially between races, indicating a role of genetics in prostate cancer development. Recently, genetic variations in the PSA gene have been related to prostate cancer risk. I aim to elucidate the molecular mechanism of this correlation and to systematically investigate the association of other novel genetic variations in PSA and related genes with prostate cancer risk in a search of sensitive clinical biomarkers for prostate cancer diagnosis and prognosis.

被诊断患有前列腺癌的男性人数在种族之间差异很大，表明遗传学在前列腺癌发展中的作用。最近，PSA基因的遗传变异与前列腺癌风险有关。我的目的是阐明这种相关性的分子机制，并系统地研究PSA和相关基因的其他新的遗传变异与前列腺癌风险的关联，以寻找敏感的临床生物标志物，用于前列腺癌的诊断和预后。