Exploring the role of miRSNPs in diagnosis and prognosis of prostate cancer

探讨 miRRSNP 在前列腺癌诊断和预后中的作用

• 批准号: nhmrc : 1090505
• 负责人: Dr Jyotsna Batra
• 金额: $ 28.54万
• 依托单位: Queensland University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/exploring-role-mirsnps-prostate-cancer/519289
• 关键词: Exploring; role; miRSNPs; diagnosis; prognosis

Genetic variants, when used alongside PSA and family history, could be a better early biomarker to identify men predisposable to develop prostate cancer or/and to distinguish slowly progressive from aggressive disease. We will undertake a comprehensive study on a special class of genetic variants "miRSNPs" in the non-coding region of the prostate cancer related genes and will also identify their mechanism of action, and their potential as a biomarker for prostate cancer diagnosis and prognosis.

当基因变异与PSA和家族史一起使用时，可能是识别易患前列腺癌的男性或/和区分缓慢进展的疾病和侵袭性疾病的更好的早期生物标志物。我们将对前列腺癌相关基因非编码区中的一类特殊的遗传变异“miRSNPs”进行全面的研究，并确定它们的作用机制，以及它们作为前列腺癌诊断和预后生物标志物的潜力。