NICHD Cooperative Multicenter Neonatal Research Network

描述(申请人提供)：杜克大学医学院新生儿学部热情提交续签申请，以继续参加由NICHD赞助的多中心合作新生儿研究网络(NRN)。NRN的目的是通过大型多中心合作试验来研究护理新生儿的治疗策略。该司对NRN研究的承诺体现在它参与研究、招募和跟踪患者，以及它提交和NRN接受涉及五名杜克大学教职员工的项目。这些研究包括与杜克大学在传染病、真菌学、普拉特工程学院和人类遗传学中心的其他研究人员的合作。这些研究包括：匿名DNA银行和链接数据库；新生儿念珠菌病的早期诊断；围产期窒息和脑室出血婴儿中APOE的患病率；以及胃食道反流：新生儿网络实践。Duke参与了以下网络试验：光疗；体温疗法治疗围产期窒息；PCV-7免疫原性；对无支气管肺发育不良患者生存率的基准干预；极低出生体重婴儿的发病率和死亡率调查；AEEG用于预测缺氧缺血性脑病的预后；肌醇与ROP飞行员的预防以及细胞因子研究。在加入该网络之前，杜克大学的教职员工参与了NICHD赞助的高频振荡试验和iNO用于预防先天BPD；以及行业赞助的CINRGI iNO用于患有肺动脉高压的足月儿和头冷用于围产期窒息的研究。新生儿-围产期医学部致力于临床研究，并得到医学院的支持，杜克转化医学奖的获奖证明了这一点。NRN的教职员工是临床研究和流行病学方面的硕士(GET，Herrera)和博士(Benjamin)，他们的参与进一步证明了我们的承诺和专业知识。值得注意的是，Duke Neonatology的患者覆盖范围在过去一年中增长了56%，因此目标是将符合NRN研究条件的患者的入院人数增加25%。该司设有一个全面的多学科后续诊所，以全面的方式接触病人，并特别注意营养。它与社区机构和服务机构合作，网络研究和通用数据库的患者返回率为380%。

DESCRIPTION (provided by applicant): The Division of Neonatology, Duke University School of Medicine enthusiastically submits this renewal application for continued participation in the NICHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to investigate treatment strategies for the care neonates through large multicenter collaborative trials. The Division's commitment to NRN research is reflected in its participation in studies, recruitment and follow-up of patients, and its submission and NRN acceptance of projects involving five Duke faculty members. These studies encompass collaborations with other Duke investigators in Infectious Diseases, Mycology, the Pratt School of Engineering and the Center for Human Genetics. These studies include: The Anonymized DNA Bank and Linked Database; Early Diagnosis of Neonatal Candidiasis; Prevalence of APOE in Infants with Perinatal Asyphxia and Intraventricular Hemorrhage; and Gastroesophageal Reflux: Neonatal Network Practices. Duke has participated in the following Network trials: Phototherapy; Body-Cooling for Perinatal Asphyxia; SUPPORT; PCV-7 Immunogenicity; Benchmarking Intervention to Increase Survival without Bronchopulmonary Dysplasia; the Survey of Morbidity and Mortality among VLBW Infants; aEEG to Predict Outcome after Hypoxic-lschemic Encephalopathy; Inositol and Prevention of ROP Pilot, and the Cytokine Studies. Prior to joining the Network, Duke faculty participated in the NICHD-sponsored High Frequency Oscillation Trial and iNO for Prevention of BPD in Premies; and the industry-sponsored CINRGI iNO Study for Term Infants with Pulmonary Hypertension and Head-Cooling for Perinatal Asphyxia studies. The Division of Neonatal-Perinatal Medicine is committed to clinical research and has the School of Medicine's support as evidenced by its receipt of the Duke Translational Medicine Award. Further evidence of our commitment and expertise is illustrated by the participation of faculty in the NRN who are Masters (Gotten, Herrera) and PhD (Benjamin) prepared in clinical research and epidemiology. Significantly, Duke Neonatology's patient catchment area has grown by 56% in the past year and as a consequence is targeted to increase admissions of patients eligible for NRN studies by 25%. The Division houses a comprehensive multidisciplinary follow-up clinic that approaches the patient in a holistic manner with special attention to nutrition. It works collaboratively with community agencies and services and has a patient return rate for Network studies and the Generic Data Base of 3 80%.