Genetic and molecular characterisation of Erg function in normal and malignant haemopoiesis

在人体内，用于携带氧气、止血和对抗感染的血细胞的产生受到高度控制。转录因子ERG在传递适当的指令以使血细胞正常发育方面至关重要。ERG过多或过少都会导致血细胞发育异常和血液疾病，如唐氏综合症儿童或急性白血病患者。将调查发生这种情况的原因，以便更好地治疗这些疾病。

In the human body, production of blood cells to carry oxygen, stop bleeding and fight infection is highly controlled. The transcription factor Erg is critical in delivering proper instructions so blood cells develop normally. Too much or too little Erg leads to abnormal blood cell development and blood diseases such as seen in children with Down Syndrome or patients who develop acute leukemia. The reasons why this happens will be investigated to allow for better treatment of these conditions.