Stem Cells and Cellular Therapies in Lung Biology and Lung Diseases

描述（由申请人提供）： 利用干细胞修复和再生病变肺是一种令人兴奋的潜在治疗多种肺部疾病的方法。越来越多的信息表明，通常不驻留在肺中的细胞可以被募集到肺中，并参与损伤后的结构和功能修复和重塑。与此同时，生物工程研究也在激增，研究使用人工基质作为三维肺再生的框架。这些研究与利用干细胞和/或细胞疗法的研究相结合是一个有前途的快速发展方向，但仍处于起步阶段。这些研究已经进一步证实了对驻留在肺中的干细胞和/或祖细胞参与肺发育以及肺损伤后修复和重塑的分子和细胞事件的理解的显著增加。 2005年7月，我们在佛蒙特大学举行了一次由NHBLI和囊性纤维化基金会赞助的“成人干细胞、肺生物学和肺部疾病”会议，该会议汇集了相关研究人员以及感兴趣的初级教师和学生，以辩论和讨论这一快速发展领域的问题。这次会议非常成功，并产生了一系列基础和翻译研究的指导方针，供研究人员和资助机构使用。这次会议也推动了NHBLI RFA“HL-07-003，肺干细胞合作研究” 生物学和基于细胞的治疗”。 随着干细胞和细胞治疗肺部疾病的研究继续快速发展，我们建议再次召集相关研究人员以及NHLBI，FDA和非营利呼吸系统疾病基金会的代表再次辩论和讨论当前的问题。特别要讨论的一个领域是基础研究和转化研究之间的平衡以及临床试验在这一领域的作用。与去年夏天的会议一样，初级研究人员和学生（研究生、博士后、研究员）将特别有针对性地参加会议讨论， 在海报会议上。作为一个新功能，学生将能够竞争的基础上盲目审查海报摘要的旅行奖。 会议计划于2007年7月在佛蒙特大学举行。潜在参与者的热情已经很高。我们预计，本次会议将再次促进广泛的讨论和辩论，并将显着指导在基础和临床研究的干细胞和细胞治疗肺部疾病的方向。

DESCRIPTION (provided by applicant): Repair and regeneration of diseased lung with stem cells is an exciting potential therapeutic approach for a variety of lung diseases. Increasing information suggests that cells normally not resident in the lung can be recruited to the lung and participate in structural and functional repair and remodeling after injury. In parallel, there has been a surge in bioengineering studies investigating use of artificial matrices as framework for three-dimensional lung regeneration. The combination of these studies with those utilizing stem cells and/or cell therapies is a promising rapidly developing direction but one that is still in its infancy. These studies have been further paralleled by significant increases in understanding the molecular and cellular events by which stem and/or progenitor cells resident in the lung participate in both lung development and in repair and remodeling after lung injury. We held a conference at the University of Vermont in July 2005, "Adult Stem Cells, Lung Biology, and Lung Disease", sponsored by the NHBLI and Cystic Fibrosis Foundation, that brought together relevant investigators as well as interested junior faculty and students to debate and discuss issues in this rapidly moving field. This conference was very successful and resulted in a series of guidelines for basic and translation research to be utilized by both investigators and by funding agencies. The meeting also was the impetus for an NHBLI RFA "HL-07-003, Collaborative Studies on Lung Stem Cell Biology and Cell Based Therapy". As studies of stem cell and cell therapies for lung diseases continues to move at a rapid pace, we propose to again convene the relevant investigators as well as representatives from the NHLBI, FDA, and non-profit Respiratory Disease Foundations to again debate and discuss current issues. One area in particular to be discussed is the balance between basic and translational research and the role of clinical trials in this area. As in last summer's conference, junior investigators and students (graduate, post-doctoral, fellow) will be particularly targeted for inclusion in both conference discussions as well as in poster sessions. As a new feature, students will be able to compete for travel awards based on blinded review of poster abstracts. The conference is planned for July 2007 at the University of Vermont. Enthusiasm is already high among potential participants. We anticipate that this conference will again foster extensive discussion and debate and will significantly guide the directions taken in basic and clinical research of stem cells and cell therapies for lung diseases.