FASEB Summer Research Conference on Lipid Signaling Pathways in Cancer

描述（由申请人提供）：本申请寻求对哈佛医学院的Alex Toker博士和宾夕法尼亚大学医学院的Marcelo Kazanietz博士组织的科学会议的部分支持。 会议由美国实验生物学学会联合会主办，将于2007年8月11日至16日在加州印第安威尔斯举行夏季研究会议（SRC）系列。 该申请寻求部分支持，以资助初级演讲者，包括研究生和博士后研究员的注册费和差旅费，他们将被邀请就其工作进行简短的演讲。 该会议的主题是“癌症中的脂质信号通路”，在4天的时间里，该领域的30多位受邀领导者将介绍这一高度相关的癌症研究领域的最新突破。 脂质信号传导领域的最新进展加强了脂质介质在癌症发生和发展中起关键作用的概念。 对甘油二酯存在多种效应的发现推动了这一领域的中心舞台。 类似地，在人类癌症中经常发现对磷酸肌醇起反应的蛋白质的突变。 其他例子包括异前列腺素信号的令人兴奋的发现，它定义了一个新的主题，即肿瘤通过促进炎症反应作为伤口。 普遍存在的Ras癌基因的脂质修饰是细胞转化所必需的众所周知的事件，因此已经被积极地靶向用于治疗干预。 该领域目前的挑战包括确定脂质介质在肿瘤进展中所起的作用，以及这些途径如何实现适当的细胞内时间和空间组织。 该领域准备将这些发现转化为治疗价值。会议将强调脂质介质及其效应物的多样性，以及每种介质如何在人类癌症中发挥关键作用。 重点也将放在这个领域的翻译方面，为观众提供最新的观点脂质信号的临床意义。

DESCRIPTION (provided by applicant): This application seeks partial support for a scientific conference organized by Dr. Alex Toker of Harvard Medical School and Dr. Marcelo Kazanietz of the University of Pennsylvania School of Medicine. The conference is sponsored by the Federation of the American Societies for Experimental Biology, and will comprise their Summer Research Conference (SRC) Series, to be held in Indian Wells, California, August 11-16, 2007. The application seeks partial support to finance the costs of registration fees and travel subsidence for junior speakers, including graduate students and post-doctoral fellows, who will be invited to present short talks on their work. The conference is entitled 'Lipid Signaling Pathways in Cancer' and over the course of 4 days, over 30 invited leaders in this field will present the latest breakthroughs in this highly relevant area of cancer research. Recent exciting developments in the field of lipid signaling have reinforced the concept that lipid mediators play a key role in the inception and progression of cancer. Discoveries on the existence of multiple effects of diacylglycerol have propelled this field center stage. Similarly, mutations in proteins which respond to phosphoinositides are often found in human cancers. Other examples include exciting findings in isoprostane signaling, which define the emerging theme that a tumor acts as a wound by promoting inflammatory responses. Lipid modifications of the ubiquitous Ras oncogene are well-known events which are essential for cellular transformation, and have thus been aggressively targeted for therapeutic intervention. Current challenges in this field include defining the roles played by lipid mediators in tumor progression, and how these pathways achieve appropriate intracellular temporal and spatial organization. The field is poised to translate these findings into therapeutic value. The meeting will emphasize the diversity of lipid mediators and their effectors, and how each one plays a key function in human cancer. Emphasis will also be placed on the translational aspects of this field to provide the audience with an up-to-date view of the clinical implications of lipid signaling.