FASEB Summer Conference: Folic Acid, Vitamin B12 and One Carbon Metabolism

描述(由申请人提供)： 请拨资金用于部分支助FASEB连续两次关于叶酸的夏季会议， 维生素B12和一碳代谢，首次会议将于2006年8月5日至10日在加利福尼亚州印第安威尔斯的凯悦大冠军度假村和水疗中心举行。这次会议继续为临床研究人员、基础科学家以及参与卫生和科学政策的人员之间进行富有成效的正式和非正式互动提供了一个极好的机会。参与者代表了来自不同学科的不同调查人员群体。此前每两年召开一次的前十届大会已全部认购一次(限量190个)。由于参加这次会议的人越来越多，我们选择了一个能容纳200多人参加的场地。组织者希望将2006年会议的登记号保持在210至220人之间。申请的资金将用于资助研究生、驻院医生、博士后研究员以及国内和国际知名调查人员的出席。为会议和研讨会选定的主题涵盖基础科学和临床科学，重点是两者之间的相互作用和潜在的协同作用。特别会议的主题包括：(1)一碳代谢：酶与调控；(2)遗传流行病学、药物遗传学、遗传变异；(3)蛋氨酸代谢；(4)同型半胱氨酸毒性；(5)遗传病；(6)叶酸和钴胺的临床和化学进展 运输；(7)一碳代谢和甲基化；(8)新的钴胺辅助因子和新的 治疗和诊断作用；以及(9)碳代谢和发育生物学。二 关于(I)一碳代谢与认知疾病和(Ii)叶酸强化与疾病的研讨会将提供叶酸强化倡议和正在进行的临床试验的最新情况，讨论叶酸和同型半胱氨酸在痴呆和神经退行性疾病中的作用，并就人群中较高叶酸状态的益处和潜在有害影响进行辩论。研讨会的形式鼓励讲演者和研究生、住院医生、研究员和初级调查人员在会议上进行讨论。海报会议突出了年轻参与者的活动，从初级参与者提交的摘要中选择的简短口头陈述的数量有所增加。

DESCRIPTION (provided by applicant): Funds are requested for partial support of two consecutive FASEB summer conferences on Folic Acid, Vitamin B12 and One-Carbon Metabolism, with the first to be held on August 5-10, 2006, at the Hyatt Grand Champions Resort and Spa, Indian Wells, California. This conference continues to offer an excellent opportunity for productive formal and informal interactions among clinical investigators, basic scientists, and those involved in health and science policy. The participants represent a diverse group of investigators from a broad range of disciplines. The previous ten conferences, which have met every second year, have been fully subscribed (at a limit of 190). Because of the increased demand for attendance at this conference, we have chosen to move to a venue capable of accommodating over two hundred participants. The orgranizers would like to keep registration numbers for the 2006 meeting in the range of 210-220 participants. The requested funds will support the attendance of graduate students, resident physicians, postdoctoral fellows, and established national and international investigators. The topics that have been selected for the sessions and workshops cover both basic and clinical science with emphasis on the interaction and potential synergy between the two. The specific session subjects include: (1) One-Carbon Metabolism: Enzymology and Regulation; (2) Genetic Epidemiology, Pharmacogenetics, Genetic Variation; (3) Methionine Metabolism; (4) Homocysteine Toxicity; (5) Inherited Disease; (6) Clinical and Chemical Advances in Folate and Cobalamin Transport; (7) One Carbon Metabolism and Methylation; (8) Novel Cobalamin Cofactors and Novel Therapeutic and Diagnositc Roles; and (9) One Carbon Metaboism and Developmental Biology. Two workshops on (i) One Carbon Metabolism and Cognitive Disease and (ii) Folate Fortification and Disease will provide updates from the folate fortification initiatives and ongoing clinical trials, discuss the roles of folate and homocysteine in dementias and neurodegeneratiion and debate the beneficial versus the potentially detrimental effects of a higher folate status in the population. The workshop format encourages discussions among the presentors and graduate students, residents, fellows and junior investigators at the meeting. The poster sessions highlight the activities of the younger participants and the number of short oral presentations chosen from abstracts submitted by junior attendees has been increased.