The International Mammalian Genome Conference

描述（由申请人提供）：国际哺乳动物基因组会议是小鼠界的流行支柱，也是国际哺乳动物基因组学会的年度会议。这个会议开始于19年前的法国巴黎，为促进对小鼠基因组的理解提供了一个论坛。最初，重点是建立物理图谱，了解小鼠品系及其变异，并开发用于模拟人类疾病的新遗传策略。现在，了解哺乳动物基因的功能相关性是一个主要目标。今天，随着小鼠基因组序列的可用，以及多个基因组序列的完成，重点仍然是模拟人类疾病，并确定涉及简单和复杂遗传疾病的新基因。新技术是一个重点，但正在朝着理解进化上保守的非编码序列和发展表型分析策略，以了解小鼠生物学和生理学。哺乳动物基因组会议的目的是1） 交流基因组计划的重要发现，2）协调新突变小鼠信息的产生和传播，3）评估比较脊椎动物生物信息学的信息资源状况，4）开发和建立“功能基因组学”战略的优先事项，包括开发用于大规模表型筛选的新检测方法和研究资源，5）促进国际和国家之间的合作研究使用小鼠作为遗传模型的研究人员，和6）指导学生和博士后研究员在小鼠遗传学，基因组学和生物学领域。 相关性：小鼠是人类疾病的主要遗传模型。国际哺乳动物 特别是基因组会议，通过遗传策略和国际合作促进人类疾病建模，以更好地利用小鼠资源。

DESCRIPTION (provided by applicant): The International Mammalian Genome Conference is a popular stanchion of the mouse community, and the annual conference of the International Mammalian Genome Society. This meeting began nineteen years ago in Paris, France, to provide a forum for promoting the understanding of the mouse genome. Initially, the focus was on building physical maps, understanding mouse strains and their variation, and developing new genetic strategies for modeling human disease. Now, understanding the functional relevance of mammalian genes is a major goal. Today, with sequence of the mouse genome available, and multiple genome sequences being completed, focus remains on modeling human diseases, and identifying new genes involved in simple and complex genetic disorders. New technologies are an emphasis, but are moving towards understanding evolutionarily conserved non-coding sequences and developing phenotyping strategies to understand mouse biology and physiology. The aims of the Mammalian Genome Conferences are 1) To communicate important discoveries of the genome project, 2) To coordinate the generation and dissemination of information on new mutant mice, 3) To evaluate the status of informatics resources for comparative vertebrate bioinformatics, 4) To develop and establish priorities for 'functional genomics' strategies, including development of new assays for large scale phenotypic screening, and research resources, 5) To foster international and national collaborative research among investigators using the mouse as a genetic model, and 6) To mentor students and postdoctoral fellows in the area of mouse genetics, genomics and biology. Relevance: The mouse is a primary genetic model for human disease. The International Mammalian Genome Conferences, in particular, promote human disease modeling through genetic strategies and through international collaborations to better utilize mouse resources.