Drug Abuse and Other Deviant Adaptations to Stress

描述（由申请人提供）： 竞争延续高级科学家（K 05）奖的候选人是摄政教授，社会学杰出教授，文科马歇尔教授，并在得克萨斯州A&M大学社会越轨行为研究实验室主任。他的工作是在一个首屈一指的研究型大学，学院，部门，实验室进行，其特点是富有成效的奖学金和研究的历史，有利于实现与研究，职业提升和指导活动有关的短期和长期职业目标。长期目标是将不断增加的专门知识应用于制定、测试和传播（通过出版和指导）关于药物滥用模式和其他异常适应的心理社会原因和后果以及这些关系的调节者和共同前提的理论信息模型。短期目标侧重于解释第二代（G2）小组的药物滥用和其他异常模式的前因和后果的变化，该小组最初在青春期早期（G2-T1）进行测试，并在K 05奖的五年期间进行了十年后（G2-T2）的随访。受试者是第一代（G1）小组的儿童，他们在7年级（G1-T1）、8年级（G1-T2）和9年级（G1-T3）期间接受了多达5次测试，作为20多岁的年轻人（G1-T4），最近在40岁的后期（G1-T5）。药物（ab）使用和其他异常模式及其在T2时对G2的后果将被建模为G1（T1- T5）和G2（T1）变量（个人访谈数据和社会环境背景的人口普查指标）的线性直接和间接（介导）影响的结果;这些相同变量的调节影响;以及共同的前因（来自相同的变量阵列）。这些模型，由候选人的偏差的综合一般理论通知，将使用结构方程/分层线性建模方法等方法进行估计。研究技能的提高将侧重于接触方法的发展，在生命历程和代际影响文献的新发现，并与使用其他纵向数据集的调查人员合作。指导活动包括指导受雇于该项目的研究生和参加由候选人讲授的研讨会的研究生，以及指导得克萨斯A&M大学和得克萨斯大学的初级教员研究药物滥用和其他异常适应的实质和方法。

DESCRIPTION (provided by applicant): The candidate for a competing continuation Senior Scientist (K05) Award is Regents Professor, Distinguished Professor of Sociology, Marshall Professor of Liberal Arts, and Director for the Laboratory for Studies of Social Deviance at Texas A&M University. His work is carried out in a premier research university, college, department, laboratory characterized by a history of productive scholarship and research that facilitates achievement of both short and long-term career goals relating to research, career enhancement, and mentoring activities. The long-term goal is to apply ever-increasing expertise to the formulation, testing, and dissemination (by publication and instruction) of theotherically informed models of psychosocial causes and consequences of patterns of drug abuse and other deviant adaptations, and the moderators and common antecedents of these relations. The short-term goal focuses upon explaining changes in antecedents and consequences of drug abuse and other deviant patterns for a second generation (G2) panel initially testing during early adolescence (G2-T1) and followed up ten years later (G2-T2) during the five-year period of the K05 award. The subjects are the children of a first generation (G1) panel who were tested up to five times during the 7th (G1-T1), 8th (G1-T2), and 9th (G1-T3) grades, as young adults in their 20s (G1-T4), and most recently in the later part of the forth decade of life (G1-T5). Drug (ab)use and other deviant patterns and their consequences for G2 at T2 will be modeled as outcomes of linear direct and indirect (mediated) influences of G1 (T1- T5) and G2 (T1) variables (both personal interview data and census indictors of socio-environmental contexts); moderating influences of these same variables; and common antecedents (drawn from the same array of variables). The models, informed by the candidate's integrative general theory of deviance, will be estimated using structural equation/hierarchical linear modeling approaches among other methodologies. Enhancement of research skill will focus upon exposure to methodological developments, new findings in the life course and intergenerational influence literature, and collaboration with investigators using other longitudinal datasets. Mentoring activities include guidance of graduate students employed on the project and in a seminar taught by the candidate, and mentoring of junior faculty at Texas A&M and the University of Texas in the substance and method of research on drug abuse and other deviant adaptations.