3.0 Tesla MRI for Psychiatric Applications

描述（由申请人提供）：高级脑成像中心（CABI）是内森·s·克莱恩精神病学研究所（NKI）内的一个基于核磁共振的多学科研究机构，由纽约州精神健康办公室（OMH）支持。CABI内的设施100%可用于临床和基础研究。该中心支持对精神健康相关疾病的大脑研究，重点是精神分裂症、阿尔茨海默病、痴呆症、衰老和药物滥用。影像学基础研究包括弥散张量成像（DTI）、BOLD-fMRI的生理基础和脑基认知、注意和感觉整合功能。新型药物治疗精神疾病的研究。在所有这些领域的科学探究，一个整体的主题被发现；脑结构成像（解剖MRI、增强MRI和DTI）检测到的脑结构与BOLD-fMRI、灌注成像、质子光谱或电生理方法检测到的所研究组织的功能使用和完整性之间的关系。该提案的目标是使获得具有并行成像技术和光谱成像能力的专用3.0 Tesla MRI成为可能，以适应正在进行的NIH资助和计划的关于精神疾病的功能后果和结构相关性的研究。该仪器及其提供的最先进的并行成像方法将加速面向患者的成像方案，提高空间分辨率和图像采集速度，并在增加信噪比的同时将几何和强度失真降低到可管理的水平。这些改进将极大地促进我们对微观结构和总体结构缺陷的研究，以及新出现的、表达的和/或慢性精神分裂症、阿尔茨海默病、痴呆和药物滥用的功能后果。光谱（代谢物）成像、功能性脑成像和DTI，这些核心的使用方法，由于其固有的对信噪比的敏感性和速度，将大大促进该仪器的使用。管理一个专注于神经精神病学研究的强大成像中心所需的基础设施支持已经到位，包括物理、技术和行政支持结构，以及监督、协议简化和审查过程。支持测试来自现有NIH研究的新假设。

DESCRIPTION (provided by applicant): The Center for Advanced Brain Imaging (CABI) is a multi-disciplinary MRI-based research facility within the Nathan S. Kline Institute for Psychiatric Research (NKI), which is supported by the State of New York Office of Mental Health (OMH). The facilities within the CABI are 100% available for clinical and basic research. The Center supports brain research into mental health related disorders with emphasis upon Schizophrenia, Alzheimer's disease, dementia and aging and substance abuse. Basic imaging research includes the physiological basis of Diffusion Tensor Imaging (DTI), BOLD-fMRI and brain-based cognition, attention and sensory integration of function. Novel drug therapies for psychiatric illness are investigated. In all these areas of scientific inquiry, an overall theme is detected; the relationship between structures of the brain, as detected by structural brain imaging (anatomical MRI, contrast enhanced MRI and DTI) and the functional use and integrity of the tissues studied, detected with BOLD-fMRI, perfusion imaging, proton spectroscopy, or electrophysiological methods. The goal of this proposal is to make possible the acquisition of a research dedicated 3.0 Tesla MRI with parallel imaging technology and spectroscopic imaging capabilities, to accommodate ongoing NIH funded and planned research into the functional consequences and structural correlates psychiatric disease. This instrumentation, and the state-of-the-art parallel imaging methodology it provides will accelerate patient oriented imaging protocols, enhance spatial resolution and image acquisition speed and reduce geometric and intensity distortions to a manageable level while increasing signal-to-noise. These improvements will greatly facilitate our investigations into micro-structural and gross structural deficits, as well as the functional consequences of emerging, expressed and/or chronic Schizophrenia, Alzheimer's disease, dementia and substance abuse. Spectroscopic (metabolite) imaging, functional brain imaging and DTI, the central measures of use, will be greatly facilitated by this instrumentation due to their inherent sensitivity to SNR and speed. The infrastructure support required to manage a strong imaging center focused on neuropsychiatric research is already in place, including physics, technician and administrative support structures, as well as oversight and protocol facilitation and review processes. Support for testing of novel hypotheses stemming from existing NIH research is provided.