Genome-based tools to support urogenital schistosomiasis control

1亿多撒哈拉以南非洲人患有泌尿生殖系统血吸虫病，这种疾病会导致恶性癌症和艾滋病毒/艾滋病。控制依赖于单一药物，使耐药性成为迫在眉睫的威胁。我们将提供新的分子工具来评估寄生虫的遗传多样性，并优先考虑一组抗寄生虫药物靶标和候选疫苗。这些结果将提供下一代针对泌尿生殖道血吸虫病的干预措施。

More than 100 million sub-Saharan Africans have urogenital schistosomiasis, a disease that promotes malignant cancer and HIV/AIDS. Control depends on a single drug, making resistance an imminent threat. We will deliver new molecular tools to assess parasite genetic diversity and to prioritise a panel of anti-parasitic drug targets and vaccine candidates. These outcomes will deliver the next generation of interventions against urogenital schistosomiasis.