Using surface-enhanced Raman spectroscopy to improve the delivery of radiotherapy in 3D tumour models

超过50%的癌症患者接受放疗作为治疗的一部分。许多患者可以治愈，但是对放射治疗有效性的抵抗仍然是一个重要的临床问题。肿瘤缺氧（低氧）等因素在确定患者对治疗的反应方面起着至关重要的作用。我们的目标是使用表面增强拉曼光谱（Sers）传感器，以了解如何提高交付放射治疗耐药肿瘤。Sers将被用作耐药肿瘤模型的分析工具，以测量肿瘤模型对治疗的反应，了解缺氧如何影响对治疗的反应，并了解如何最好地向缺氧肿瘤提供放射治疗。

Over 50% of all cancer patients receive radiotherapy as part of their treatment. Many patients may be cured, however resistance to the effectiveness of radiotherapy remains a significant clinical problem. Factors such as tumour hypoxia (low oxygen) play a crucial role in determining patient response to therapy. Our objective is to use surface-enhanced Raman spectroscopy (SERS) sensors to understand how to improve the delivery of radiotherapy to resistant tumors. SERS will be used as an analytical tool in models of resistant tumors to measure the response of the tumor model to therapy, to understand how hypoxia affects the response to therapy, and to understand how best to deliver radiotherapy to hypoxic tumors.