CHEMICAL-BIOLOGY INTERFACE TRAINING GRANT

这是一份重新提交的培训补助金申请T32 GM 08804。我们设计了一个跨学科的计划，用于培养学生（和教师）在生物，医药和传统化学的接口，称为生物化学计划（BCP）。该计划于2000年秋季开始，为对生物化学感兴趣的学生提供重点，跨学科的教育。一旦完全参与，我们设想40 - 50名学生参加BCP在任何给定的时间。该计划完全融入三个参与部门，学生可以获得化学，生物化学和分子学学位 生物物理学，或药物化学，同时参加生物化学培训计划。这个建议是为培训补助金的支持，将允许四个奖学金pe_：year被授予最好的学生在该计划为期两年（每年8个总奖项）。奖学金将在学生的第二学期结束时颁发，在选择论文导师之前，将允许学生在选择论文主题方面有更多的自由，并为学生参加全国会议提供资金。学生将继续活跃在BCP，直到毕业。培训教师包括35名 来自四个部门的高度活跃的研究小组。之前提交的论文获得了我们的培训教师，我们对跨学科研究的承诺，我们的互动，融洽的学术环境以及我们最先进的研究设施的赞誉。主要的问题是，我们还没有很多学生。还有两个小问题是，我们的行政和课程的所有方面都没有得到实施。在过去的一年里，我们成功地招募了12名新学生加入我们的计划，使我们的总人数达到16人。其中，7人可获得培训补助金。/El我们的E-ram方面，包括专门为E-ram设计的新课程，现在已经到位。修订后的提案已作修改，以反映这些进展，并解决审查人员的所有关切。

This is a resubmission of training grant application T32 GM08804. We have designed an interdisciplinary program for training students (and faculty) at the interface of biological, medicinal, and traditional chemistry, called the Biological Chemistry Program (BCP). This program, which began in the fall of 2000, provides a focused, cross-disciplinary education for students interested in biological chemistry. Once fully engaged, we envision 40 - 50 students participating in the BCP at any given time. The program is fully integrated into the three participating departments and students may obtain a degree in Chemistry, Biochemistry and Molecular Biophysics, or Medicinal Chemistry while participating in the Biological Chemistry Training Program. This proposal is for training grant support that would allow four fellowships pe_: year to be awarded to the best students in the program for a period of two years each (8 total awards per year). The fellowships will be awarded at the end of the student's second semester, before theft choose a thesis advisor, and will allow the student more freedom in choosing a thesis topic as well as provide funds for student travel to national meetings. The students will remain active in the BCP until graduation. The training faculty include 35 highly active research groups from four departments. The previous submission received hitch praise for our training faculty, our commitment to interdisciplinary research, our interactive, congenial academic environment, and our state-of-the-art research facilities. The major concern identified was that we did not yet have many students. Two more minor concerns were that not all aspects of our administration and curriculum were implemented. In the past year, we have successfully recruited 12 new students to our program, bringing us to 16 total. Of these, 7 are training grant eIigible. /El aspects of our prog-ram, including a new course specifically desig-ned for the prog-ram, are now in place. The revised proposal has been modified to reflect these advances and addresses all of the reviewers' concerns.