Pre-doctoral Training Program in Integrative Vascular Biology

描述（由申请人提供）： 心血管疾病的发病机制复杂。然而，受过处理整个生物体疾病培训的调查人员人数正在减少。因此，我们建议培养未来的血管生物学家，能够通过博士前培训期间开始的多学科合作，实施结合“细胞”，“整个动物”和“人类”系统的综合方法。我们在北卡罗来纳州大学开发了一个跨学科的综合血管生物学（IVB）博士前培训计划，其既定目标是刺激学生合作，并将他们团结为一个IVB小组。IVB计划于四年前开始，由目前的T32资助，迄今为止取得了成功，从AHA和其他来源获得个人奖学金的受训人员人数（7/16）以及受训人员在各种会议上获得的旅行/海报奖（共17）可以清楚地证明。该计划还刺激了整个血管生物学研究在密歇根大学校园。此更新申请要求资金继续我们的IVB计划，每年为15名博士前学员提供支持。受训人员将从已经在斯坦福大学就读的研究生中挑选，并将获得长达三年的支持。为了鼓励多学科的方法，我们要求每个学员除了传统的主要导师外，还有合作顾问。IVB计划由全校分子生物学和生物技术计划管理。病理学和实验室医学教授Nobuyo Maeda博士是主任，遗传学教授Mark Majesky博士是联合主任。主要的论文顾问是教师（来自三所学校的12个部门和一所大学），通过分子，细胞和整个生物体水平的血管生物学相关研究，坚定地致力于博士前培训。为了形成一个补充教师的机构，学员可以选择与之合作，初级培训机构由临床教师和科学家加入，他们主要与博士后学生保持活跃的实验室，并由研究三角区附近机构的研究人员加入。凭借其在血管生物学研究方面的杰出历史，其强大的研究人员团队以及其在动物模型研究方面的实力，IVB计划为博士前学生的多学科培训提供了出色的环境。

DESCRIPTION (provided by applicant): The pathogenesis of cardiovascular diseases is complex. Yet the number of investigators trained to deal with whole organism diseases is decreasing. Accordingly, we propose to train future vascular biologists capable of implementing integrated approaches combining "cellular", "whole animal" and "human" systems through multidisciplinary collaborations that begins during pre-doctoral training. We have developed an interdisciplinary program for predoctoral training in Integrative Vascular Biology (IVB) at the University of North Carolina with the stated goal of stimulating students to collaborate, and to unite them as an IVB group. The success of the IVB Program to date, which began four years ago with the curren T32 funding, is clearly, demonstrated by the number of trainees who went on to obtain individual fellowships from AHA and other sources (7/16) and of travel/poster awards earned by the trainees at various meetings (total 17). The program has also stimmulated overall vascular biology research on UNC campus. This renewal application requests a funding to continue our IVB Program with a support for 15 pre-doctoral trainees per year. Trainees will be selected from graduate students already enrolled in departmental programs and curricula at UNC, and will be suported for up to three years. To encourage the multi-disciplinary approach, we require each trainee to have collaborating advisor(s) in addition to the conventional primary mentor. The IVB Program is administered by the campus-wide Program for Molecular Biology and Biotechnology. Dr. Nobuyo Maeda, Professor of Pathology and Laboratory Medicine, is the Director, and Dr. Mark Majesky, Professor of Genetics, is the Co-Director. The primary thesis advisors are faculty members (from 12 Departments in three Schools and one College at UNC), with a strong commitment to predoctoral training through vascular biology related research at the molecular, cellular, and whole organism levels. To form a body of complementing faculty with whom the trainees can choose to collaborate, the primary training faclty is joined by clinical faculty and scientists at UNC, who maintain active laboratories mainly with postdoctoral students, and by investigators at nearby Institutions in the Research Triangle area. With its outstanding history in vascular biology research, its strong group of investigators, and its strength in animal model studies, the IVB Program at UNC offers an outstanding environment for multidisciplinary training of pre-doctoral students.