Graduate Training in Biochemistry and Molecular Biology

现代生物学正在进入一个新时代。多种生物的基因组已经完全被 测序和众多基因组规模的项目正在进行中。这些项目正在产生大量的 潜在基因产物的数据库，RNA和蛋白质表达谱，与 基因类型和结构信息。这一信息为史无前例的 生物学洞察力，这对生物医学研究具有巨大的影响潜力。然而，它将是 关键是对新科学家进行培训，使其利用这些生物信息。三个基本要素 21世纪优秀科学家的特征是：1)基本的科学知识 复杂的生化、分子和细胞过程，共同控制生理 正常状态和疾病状态下的动态平衡。2)理解和利用信息的能力 来自多个学科，以开发新的生物学见解。3)有效沟通的能力 以口头和书面形式向其他科学家提供研究目标和科学成果，以 教育者、立法者和普通公民。为了训练个人具备这些必要的技能， 八年前，我们制定了一个跨部门的博士培训计划，强调 跨学科的科学研究方法侧重于生物化学、分子和 细胞生物学。这笔赠款是培训赠款的第一次续期，该赠款部分支持 该项目中的学生。这一群体所代表的研究专业知识的深度和广度 他们对研究生教育的承诺是 拟议的跨学科培训。

Modern biology is entering a new era. The genomes of multiple organisms have been completely sequenced and numerous genomic scale projects are ongoing. These projects are generating vast databases of potential gene products, RNA and protein expression profiles, phenotypes linked to genotypes, and structural information. This information provides the foundation for unprecedented biological insight, which has great potential to impact on biomedical research. However, it will be critical that new scientists be trained to take advantage of this biological information. Three essential attributes will characterizeexcellent scientists of the 21st century: 1)A fundamental knowledge of the complex biochemical, molecular and cellular processes that together control physiological homeostasis under normal and diseased states. 2) The ability to understand and utilize information from multiple disciplines to develop new biologicalinsights. 3)The ability to effectively communicate research objectives and scientific findings in both oral and written form, to other scientists, to educators, to legislators, and lay citizens. In order to train individuals with these necessary skills, eight years ago we developed an interdepartmental Ph.D. training program that emphasizes an interdisciplinary approach to scientific research focused on the areas of biochemistry, molecular and cellular biology. This grant is the first renewal of the training grant that partially supports the students within the program. The depth and breadth of research expertise represented by this group of researchers, and their commitment to graduate education is the underlying foundation for the proposed interdisciplinary training.