Training to Improve Cardiovascular Therapies

描述（由申请人提供）： 该计划的目标是培养有前途的新科学家在心血管疾病的机制，实验策略和必要的新分子疗法的发展技术。该计划的主题是多学科综合计划中的信号转导，重点关注心血管发育，蛋白质组学，心脏干细胞和再生医学以及心血管疾病的分子基础的分子事件。未来几十年，我们对心血管疾病分子结构和功能的理解将取得快速进展，并有望将这些见解成功应用于开发新的治疗方法和预防心血管疾病。这些进展将需要训练有素、精力充沛和富有成效的科学家，他们有能力在生理背景下理解和操纵分子事件。这些是我们打算通过这个培训计划的综合博士前和博士后组成部分开发的个人类型。这37名导师合格的教师是根据他们对心血管疾病的研究兴趣，积极的NIH研究支持，正在进行的合作，成功的培训和指导经验，以及对博士前和博士后培训的承诺而选择的。项目主任和联合主任由一个项目指导委员会和一个由心血管生物学领域杰出专家组成的外部咨询委员会协助。培训计划的关键组成部分是导师研究经验，提供心血管疾病的广泛视角的教学课程，所需的培训和负责任的研究行为，选修课程，心血管杂志俱乐部，研讨会，在区域和国家会议上的演讲，以及专业发展活动。心血管杂志俱乐部，研讨会，研讨会和学生研究日为所有学员提供了一个框架，让他们在培训期间进行互动，合作和共同工作。将使用一个综合性的多年评价计划来衡量方案目标和目的实现的程度。我们的目标是培养对心血管功能障碍有广泛见解的杰出研究人员，他们为了解这些疾病和开发心血管疾病的治疗方法做出了重大贡献。

DESCRIPTION (provided by applicant): The program objective is to train promising new scientists in mechanisms of cardiovascular diseases, experimental strategies and technologies necessary for development of novel molecular therapeutics. The theme of the program is signal transduction within a multidisciplinary, integrated program that focuses on molecular events in cardiovascular development, proteomics, cardiac stem cells and regenerative medicine as well as the molecular basis of cardiovascular disease. Future decades will see rapid advances in our understanding of the structure and function of molecules involved in cardiovascular disease and hopefully the successful application of these insights into the development of novel treatments and prevention of cardiovascular diseases. Such advances will require well-trained, energetic and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals that we intend to develop through the integrated predoctoral and postdoctoral components of this training program. The 37 mentor-eligible faculty members were selected on the basis of their research interests related to cardiovascular diseases, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to predoctoral and postdoctoral training. The Program Director and Co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of cardiovascular biology. Key components of the training program are the mentor research experience, didactic courses providing a broad perspective of cardiovascular disease, required training and responsible conduct of research, elective courses, cardiovascular journal club, seminars, presentations at regional and national conferences, and professional development activities. The cardiovascular journal club, seminars, workshops and student research day provide a framework for all trainees to interact, collaborate, and work together during their training experience. An integrative, multi-year evaluation plan will be used to measure the extent to which the program goals and objectives are met. Our aim is to produce outstanding investigators with a broad insight into cardiovascular dysfunction who make significant contributions to the understanding of these disorders and development of therapies for cardiovascular diseases.