Molecular Mechs.Regulating Cancer Cell Proliferation

描述（由申请人提供）：这个博士后培训项目，“调节癌细胞增殖的分子机制”，由来自威斯康星大学麦迪逊分校10个部门的22名科学家组成，他们对癌细胞生物学有一般兴趣，对维持肿瘤细胞增殖的分子有特殊兴趣。要求为六个培训职位提供经费。该计划的目标是培养博士、博士和医学博士级别的科学家，使他们掌握与癌症生物学这方面相关的问题和技术，从而成为独立的研究人员，拥有自己的研究项目。在完成培训计划后，这些科学家应该能够竞争学术，政府或企业生物医学研究部门的最佳职位。在调控分子分析方面受过培训的研究人员，包括生长因子、生长因子受体、原癌基因、转录因子和细胞外基质中的分子，可能会从事影响我们对癌症病因的理解的研究，并建立对特定肿瘤的分子检测和诊断有用的系统。

DESCRIPTION (provided by applicant): This Postdoctoral Training Program, "Molecular Mechanisms Regulating Cancer Cell Proliferation," consists of 22 scientists from 10 departments at the University of Wisconsin-Madison who have a general interest in cancer cell biology and specific interests in the molecules that maintain the proliferation of neoplastic cells. Funds are requested for six training positions. The goal of this program is to train Ph.D.-, D.V.M.- and M.D.-level scientists in the questions and techniques relevant to this aspect of cancer biology so that they can become independent researchers with their own research programs. Upon completion of the training program, these scientists should be able to compete for the best positions in academic, government, or corporate biomedical research departments. Investigators trained in the analysis of regulatory molecules, including growth factors, growth factor receptors, proto-oncogenes, transcription factors, and molecules in the extracellular matrix, may pursue research that will affect our understanding of cancer etiology and establish systems useful in the molecular detection and diagnosis of specific tumors. The training program is designed to provide each trainee with a primary mentor (trainer) in whose laboratory the trainee will be instructed in the specific questions and techniques relevant to the research of the mentor's laboratory. The trainee will participate in the research effort and should make specific contributions to the research progress, which will be submitted to peer-reviewed journals for publication. In addition, the training program provides to the trainees a broader exposure to experimental approaches in tumor cell biology and to the clinical application of these approaches through mandatory participation in the program activities. Finally, the progress of each trainee in his or her research and in the other activities of the program will be evaluated annually by an Evaluation Committee made up of the Program Director and four senior trainers in the program. This evaluation will provide the trainee with constructive criticism through oral and written evaluations. The members of the Evaluation Committee will strive to help the mentors provide the trainees with the best possible preparation for independent careers in cancer research.