SOLID TUMOR PHARMACOLOGY CORE

实体瘤药理学核心的职能是： A.进行测定，以定量采集的生物样本中的药物和药物代谢产物浓度 作为本项目临床前和临床药代动力学研究的一部分。 B。分析从临床前和临床药代动力学研究中获得的药代动力学数据， 根据研究者的要求，为数据建立适当的药代动力学和药效学模型， 程序. C.对本项目内开展的临床试验的患者样本进行基因分型研究。 D.维护实体瘤药理学核心中进行的分析数据的计算机数据库， 并根据需要生成数据检索和报告。 E.根据需要执行额外的特殊实验室程序，以支持本文件中包含的项目。 程序.

The functions of the Solid Tumor Pharmacology Core are to: A. Perform assays to quantitate drug and drug metabolite concentrations in biological specimens collected from animals and patients as part of preclinical and clinical pharmacokinetic studies within this Program. B. Analyze pharmacokinetic data obtained from preclinical and clinical pharmacokinetic studies, and fit appropriate pharmacokinetic and pharmacodynamic models to the data, as requested by investigators in this Program. C. Perform genotyping studies on patient samples from clinical trials conducted within this Program. D. Maintain computer databases of data from analyses performed in the Solid Tumor Pharmacology Core, and generate data retrievals and reports as required. E. Perform additional special laboratory procedures as required to support the projects included in this Program.