Glucose toxicity-induced activation of the Bcl-2-regulated apoptotic pathway in pancreatic beta cells

高血糖或高血糖是2型糖尿病的一个特征。血液中的高血糖和脂肪酸会导致产生胰岛素的胰岛β细胞受损，导致糖尿病恶化。我们计划阐明高水平葡萄糖和脂肪酸刺激的β细胞中的通路，并确定这些通路是否在2型糖尿病患者的胰腺中启动，以尝试并确定新疗法的靶点。

High blood glucose or hyperglycaemia is a feature of type 2 diabetes. Hyperglycaemia and fatty acids in the blood can cause damage of the insulin-producing pancreatic beta cells, resulting in worsening of diabetes. We plan to elucidate the pathways in beta cells that are stimulated by high levels of glucose and fatty acids, and to determine if these pathways are turned on in the pancreas of patients with type 2 diabetes, to try and identify targets for new therapies.