SEARCH for Diabetes in Youth 2: Ohio Center

这项建议建立在一个为期五年的研究项目--寻找青年糖尿病，其标准化数据的基础上 收集工作，经验丰富的调查团队，建立的案件查明基础设施，以及种族 人口基础多样化。这是一个来自六个搜索临床站点的常见的集成应用程序，其中 建议继续并扩大搜索所开展的工作，以解决以下具体问题 研究目标：目标1：前瞻性确定新诊断(2006-2009年)年龄以下的事件病例 20年，以评估青年糖尿病发病率的时间趋势；目标2：进行纵向研究 2002-2005年已招募进行搜索的事件案件的后续行动，以记录 根据临床和生化因素新诊断的糖尿病；目标3：在 头五年搜索并扩大护理质量评估的范围，以涵盖更广泛的范围 已定义的质量概念和衡量标准；目标4：制定和验证简单和低成本的案例定义 以及可用于公共卫生监测的青年糖尿病类型分类。它的新奇之处在于 提案包括其综合性，汇集了儿童DM的主要和及时的方面 研究：一项在美国独一无二的流行病学研究，研究了#年糖尿病发病率的时间趋势 青年：一种研究青年糖尿病自然病史的病理生理学成分；对 护理和生活质量；以及从公共卫生角度对青年糖尿病病例进行分类。这项研究是 对公众健康至关重要，因为它将提供关于DM是否和多少的信息 在美国不同种族/民族的年轻人中，关于DM如何影响 身体健康，包括并发症，以及关于护理质量和质量的宝贵数据 这些年轻人的生活。俄亥俄州的主要地区是辛辛那提的主导市场。 儿童医院医学中心(CCHMC)，CCHMC对研究和糖尿病护理的承诺， CCHMC与周围社区有良好的融洽关系，以及俄亥俄州搜索的跟踪记录 调查人员成功合作的关键。基于这些优势，俄亥俄州的网站使用了全面的 CCHMC的糖尿病患者数据库，并建立了一个社区网络来确定99.8%(估计为 SEARCH1俄亥俄州地理区域青年糖尿病病例的捕获-再捕获分析)。

This proposal builds upon a five year research project, SEARCH for Diabetes in Youth, its standardized data collection effort, experienced investigator team, established case ascertainment infrastructure, and ethnically diverse population base. This is a common, integrated application from the six SEARCH clinical sites, which proposes to continue and expand the work performed by SEARCH in order to address the following specific research aims: AIM 1: Prospectively ascertain newly diagnosed (2006-2009) incident cases age less than 20 years in order to estimate temporal trends in incidence of DM in youth; AIM 2: Conduct longitudinal follow-up of incident cases already recruited to SEARCH in 2002-2005 in order to document the evolution of newly diagnosed DM according to clinical and biochemical factors; AIM 3: Complete analyses initiated in the first five years of SEARCH and expand the scope of quality of care assessment to encompass more broadly defined concepts and measures of quality; AIM 4: Develop and validate simple and low-cost case definitions and classifications of DM types in youth that can be used for public health surveillance. The novelty of this proposal includes its comprehensive nature that brings together major and timely facets of childhood DM research: an epidemiologic study, unique in the United States, of temporal trends in the incidence of DM in youth; a pathophysiologic component addressing the natural history of DM in youth; a study of processes of care and quality of life; and a public health perspective on case classification of DM in youth. This research is critically important to public health as it will provide information about whether and how much DM is increasing among youth of different racial/ ethnic groups in the United States, about how DM impacts on the physical health, including complications, as well as valuable data regarding the quality of care and the quality of life of these youth. The major stengths of the Ohio site are the dominant market postion of Cincinnati Childen's Hospital Medical Center (CCHMC), CCHMC's commitment to research and diabetes care, the excellent rapport CCHMC has with the surrounding community, and the track record of Ohio SEARCH investigators for successful collaboration. Based on these strengths, the Ohio site used a comprehensive diabetes patient database at CCHMC and built a community network to ascertain 99.8% (estimate by capture-recapture analysis) of the cases of diabetes in youth in the Ohio geographic area in SEARCH1.