Goblet cell stress and intestinal inflammation

我们已经产生了症状反映炎症性肠病，溃疡性结肠炎（UC）的小鼠。这些小鼠产生肠内保护性黏液层主要成分的基因发生了突变。这种突变导致了一种被称为内质网应激的现象。我们已经证明内质网应激也发生在UC中，开启了对这种疾病的新认识。拟议的研究将探索内质网应激和炎症之间的联系，并测试UC的潜在新治疗方法。

We have generated mice with symptoms mirroring the inflammatory bowel disease, ulcerative colitis (UC). These mice have mutations in the gene producing the major component of the protective mucus layer in the intestine. The mutations lead to a phenomenon known as ER stress. We have shown that ER stress also occurs in UC, opening up a new understanding of this disease. The proposed research will explore links between ER stress and inflammation and test potential new treatments for UC.