The role of microRNAs in the regulation of gene expressi

为了充分利用基于RNAi的技术，尽可能充分地了解RNAi的内生作用(S)和相关途径是至关重要的。GSS和ABCC的Bob Stephens之间的合作已经建立，以开发一种生物信息学方法来评估miRNAs在癌症中的作用。斯蒂芬博士的团队使用了已发表的miRNA靶标算法，并将其改进为一种算法，允许在所有RefSeq数据库中搜索miRNA靶标。我们还与柯蒂斯·哈里斯博士合作，研究miRNAs在肺癌发生中的作用--这项工作目前正在审查中。最后，我们目前正在帮助5名CCR研究人员进入一个中等吞吐量的平台来分析miRNA的表达

To fully exploit technologies based on RNAi it is critical to have as full an understanding as possible of the endogenous role(s) of RNAi and related pathways. A collaboration between GSS and Bob Stephens at ABCC has been established to develop a bioinformatic approach to assessing the role of miRNAs in cancer. Dr. Stephen's group has used the published miRNA target algorithms and has now refined these into one algorithm that allows for a search of miRNA targets across all RefSeq databases. We have also collaborated with Dr. Curtis Harris on his studies investigating the role of miRNAs in the development of lung cancer - work that is currently under review. Finally, we are currently assisting 5 CCR investigators access a medium throughput platform for the analysis of miRNA expression