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Design Of Immunogens

Design Of Immunogens
免疫原的设计
批准号：
7299829
负责人：
Peter D Kwong
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7299829
关键词：
DesignImmunogens

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中文摘要
翻译
基于我们对体液逃避机制的理解，我们试图设计基于体液逃避的免疫原，使这些机制失效。这种具有减弱的防御的修饰的免疫原可以引发更广泛的中和抗体。我们还设计了支架技术，作为呈现广泛中和抗体的表位的结构模拟物以帮助其重新引发的手段。
英文摘要
Based on our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised scaffolding technology, as a means of presenting structural mimics of the epitopes of broadly neutralizing antibodies to assist in their re-elicitation.
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会议论文
CAPRISA HIV-1 neutralizing antibodies: Harnessing ontogeny for immunogen design
Design Of Immunogens
Mechanisms Of Humoral Evasion
Computational Tools for Protein Crystallization and Structural Analysis
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