Personal Patient Profile-Prostate (P4) Randomized, Multi-site Trial

描述（由申请人提供）：没有其他前列腺癌高发病率的疾病有如此多的选择，但确定性如此之少。局部前列腺癌（LPC）可采用一种或多种治疗方式，包括单独观察、手术、冷冻手术、激素治疗、近距离治疗或外束放射治疗。目前还没有关于这些治疗方式的完整的随机研究。前列腺癌治疗的并发症，性、膀胱和肠功能障碍不能轻易地比较不同的治疗方式。越来越多的证据表明，患有LPC的男性在做决定时，会考虑他们的个人特征和因素，这些因素可能比任何医疗因素都更有影响力。一个量身定制的决策支持系统已经开发和试点测试，以提高男性的个人因素澄清，搜索信息和经验的专家咨询医师专家。这项随机研究的目的是比较接受个人患者档案-前列腺（P4）和传统患者教育策略的男性的决策冲突和满意度。子目标包括决策控制转移、生活质量和资源利用的比较。498名患有局限性前列腺癌的男性，他们正准备与泌尿科医生和/或放射肿瘤科医生进行会诊，讨论治疗方案。一项多地点试验将在北美不同的地理位置进行。干预将在临床医生办公室或在有宽带互联网接入的参与者家中进行。

DESCRIPTION (provided by applicant): No other disease condition with the high incidence of prostate cancer has so many alternatives with so few certainties. Localized prostate cancer (LPC) can be treated with one or more of several modalities including observation alone, surgery, cryosurgery, hormonal therapy, brachytherapy, or external beam radiation therapy. There are no completed, randomized studies of these treatment modalities. The complications of prostate cancer treatment, sexual, bladder, and bowel dysfunction cannot be easily compared between modalities. There is a growing body of evidence that men with LPC conduct the decision making process by considering their personal characteristics and factors which may be much more influential than any medical factor. A tailored, decision support system has been developed and pilot-tested to enhance men's personal factor clarification, search for information and experiences in expert consultation with physician specialists. The purpose of this randomized study is to compare decisional conflict and satisfaction in men receiving the Personal Patient Profile - Prostate (P4) and traditional patient education strategies. Sub-objectives include comparisons of decisional control shift, quality of life and resource utilization. An ethically and racially diverse sample of 498 men with localized prostate cancer who are preparing for a planned consult visit with a urologist and/or radiation oncologist in which treatment options are discussed. A multi-site trial will be conducted in geographically diverse locations in North America. The intervention will be delivered in both clinician offices or in participant's homes with broad-band Internet access.