Emotion and Cognition on Gene, Cell, and Systems Levels

描述(由申请人提供)： 这项申请寻求为这个少数群体服务机构的专门神经科学研究计划(SNRP)继续提供资金。在前一次资助期间，SNRP的目标是提高这个校园的神经科学研究能力，而本申请旨在通过建立一个有重点和协调的团队研究计划，在先前成功的基础上再接再厉。这项计划将探讨“基因、细胞和系统层面上的情绪和认知”，主要关注压力和焦虑对情绪和认知的影响，认识到增加对这些相互作用的了解对人类健康至关重要。 该提案汇集了广泛的跨学科经验(包括精神病学、心理学、分子生物学、神经成像、遗传学、神经解剖学、神经药理学、电生理学、生物化学和动物行为学)，以解决这一总体问题的四个具体方面，利用人类受试者和动物模型(目标1)。然而，团队研究的需求将与提供一个精心构建的计划的需要相平衡，该计划将促进SNRP参与者在所有级别的个人学术发展(目标2)。此外，这项提案将试图证明生物医学科学中团队研究的有效性，例如刺激这一领域的更多团队研究努力(目标3)。最后，这项建议旨在为这所大学的神经科学(目标4)建立一个强大而有凝聚力的学术和研究培训“中心”，这样随着时间的推移，这所大学将成为国内和国际神经科学研究和培训的资源。具体项目的标题是：压力诱导的CRF对恐惧和焦虑的作用；压力对杏仁核CRF和情绪的影响；甲基苯丙胺精神病：人和鼠的模型；CRF系统和防御行为。该提案提供了一个多肽和DNA技术核心来支持这些项目。

DESCRIPTION (provided by applicant): This application seeks continuation funding for a Specialized Neuroscience Research Program (SNRP) at this minority serving institution. Whereas the goals of the SNRP during the previous funding period were to increase Neuroscience research capacity on this campus, the present application seeks to build on that previous success by establishing a focused and coordinated, team research, program. This program will address "Emotion and cognition on gene, cell and systems levels", with a primary focus on the effects of stress and anxiety on emotion and cognition, recognizing that increased understanding of these interactions is of major importance to human health. The proposal brings together a wide range of interdisciplinary experience (including psychiatry, psychology, molecular biology, neuroimaging, genetics, neuroanatomy, neuropharmacology, electrophysiology, biochemistry and animal behavior) to address four specific aspects of this overall problem, utilizing both human subjects and animal models (Aim 1). Nevertheless, the demands of team research will be balanced by the need to provide a carefully constructed program that fosters individual academic development of SNRP participants at all levels (Aim 2). Additionally, this proposal will attempt to demonstrate the effectiveness of team research in the biomedical sciences, such as to stimulate additional team research efforts in this area (Aim 3). Finally, this proposal seeks to generate a strong and cohesive academic and research training "center" for the Neurosciences at this University (Aim 4), such that this University will become known over time as a national and international resource for Neuroscience research and training. Titles of the specific projects are: Stress-induced CRF actions on fear and anxiety; Stress effects on amygdalar CRF and emotion; Methamphetamine psychosis: a model in man and mouse; CRF systems and defensive behavior. The proposal provides a Peptide and DNA Technology Core to support these projects.