Poverty, Stress and Cardiovascular Disease

描述（由申请人提供）：低社会经济地位（SES）的老年妇女比高SES的老年妇女有更高的心血管疾病（CVD）患病率。这种差异是死亡率和残疾差异的一个来源，不能用传统的CVD风险因素来解释。尽管最近的政策强调健康差异，但造成差异的生物学机制在很大程度上没有明确说明。SES组之间的差异压力经验可能会影响CVD的差异。非稳态负荷是代表多个身体系统指标总和的单个参数，理论上是压力相关生物风险的累积度量。本研究的目的是检验这一假设，即非稳态负荷是一个中介之间的SES和事件心血管疾病的老年妇女的人口。该研究将使用来自妇女健康和衰老研究2的数据，这是一项为期10年的纵向研究，共有436名年龄在70-79岁之间的妇女参加。受试者的社会经济多样性和提供的生物数据范围是测试候选人假设的理想选择。采用非稳态负荷的理论在一个样本的老年妇女的广泛的SES范围内可能提供重要的洞察机制，有助于在CVD的健康差距的重大问题。

DESCRIPTION (provided by applicant): Older women of low socioeconomic status (SES) have higher prevalence of cardiovascular disease (CVD) than older women of high SES. This difference, a source of disparity in mortality and disability, is not explained by traditional CVD risk factors. Despite recent policy emphasis on health disparities, the Contributing biological mechanisms are largely unspecified. Differential stress experience between SES groups could affect CVD disparities. Allostatic load is a single parameter that represents the sum of multiple body system indicators and is theorized to be a cumulative measure of stress-related biological risk. The purpose of this study is to test the hypothesis that allostatic load is a mediator between SES and incident CVD in a population of older women. The study will use data from the Women's Health and Aging Study 2, a 10 year longitudinal study of 436 women aged 70-79 years old at baseline. The socioeconomic diversity of the subjects and the range of biological data provided are ideal to test the candidate's hypotheses. Employing the theory of allostatic load in a sample of older women of a wide SES range may provide important insight into mechanisms contributing to the significant problem of health disparities in CVD.