MECHANISMS OF HYPERTRIGLYCERIDEMIA IN HUMANS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 胆固醇和甘油三酯是血液中的两种脂肪，因为它们与早期冠状动脉疾病有关。血液中的甘油三酯是由极低密度脂蛋白（VLDL）携带的。本研究的目的是确定：1）与VLDL过度产生和/或与脂蛋白脂肪酶或肝脂肪酶相关的VLDL催化缺陷相关的原发性高脂血症的机制; 2）上述与继发性高脂血症的相互作用; 3）LDL大小、组成和质量对VLDL变化的反应。对这些受试者的研究将有助于了解各组胆固醇和甘油三酯代谢紊乱的病理生理机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cholesterol and triglyceride are two fats of interest in blood because they are associated with early coronary artery disease. Triglyceride in blood is carried in very low density lipoproteins (VLDL). The purpose of this study is to determine: 1) the mechanisms of primary hypertriglyceridemia related to VLDL overproduction and/or defective VLDL catabolism related to lipoprotein lipase or hepatic lipase; 2) the interaction of the above with secondary forms of hypertriglyceridemia; and 3) the response of LDL size, composition and mass to changes that occur in VLDL. The study of these subjects will help to understand the pathophysiological mechanisms of each group of disorders of cholesterol and triglyceride metabolism.