COGNITIVE EFFECTS OF OPIOIDS IN OLDER ADULTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 持续性疼痛，足以导致日常功能严重受损，影响多达50%的老年人。到目前为止，还没有研究检查或表征阿片类药物对老年人的神经认知影响。这项拟议的研究将测量即时释放羟考酮对健康老年人(65岁)的客观和主观神经认知影响。我们还将在特定剂量水平下表征药代动力学和药效学。由于老年人对阿片类药物的反应模式可能与年轻人不同，我们还将在健康的中年(35-55岁)样本中测量羟考酮的客观和主观神经认知效应和药代动力学。我们将使用随机、双盲、交叉设计，通过比较中老年人群的神经认知功能来检验老龄化的影响。这个项目代表了一个新的研究领域，因为到目前为止，还没有关于阿片类药物对老年人神经认知影响的严格对照研究。目前在健康、疼痛幼稚的老年人中进行的这项研究将允许对口服阿片类药物的神经认知影响进行明确评估，而不会出现疼痛和其他疾病变量的并发症。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent pain, sufficient to cause significant impairment in daily functioning affects up to 50 percent of older adults. To date, no studies have examined or characterized neurocognitive effects of opioids in older adults. The proposed study will measure the objective and subjective neurocognitive effects of immediate release oxycodone in healthy older (>65 years) adults. We will also characterize the pharmacokinetics and pharmacodynamics at a specified dose level. Because older adults may evidence a different pattern of response to opioid medication than younger adults, we will also measure objective and subjective neurocognitive effects and pharmacokinetics of oxycodone in a healthy middle age (35-55 years) sample. We will examine aging effects by comparing neurocognitive function of the middle aged and older adults groups using a randomized, double-blind, cross-over design. This project represents a novel area of inquiry because to date there have been no rigorously controlled studies of the neurocognitive effects of opioids in older adults. The present study conducted in healthy, pain-naive older adults will permit an unambiguous assessment of the neurocognitive effects of an oral opioid, without the complications of pain and other disease variables.