PCB STUDY FOR CHILDREN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据认为，有证据表明高暴露于多氯联苯的儿童在评估执行功能、记忆力和注意力的神经行为和神经认知测试中的表现会比来自相同地区的低暴露儿童更差。这项研究的相关性在于，多氯联苯暴露对儿童一般认知能力的影响的性质尚不清楚，尽管早期研究表明，儿童暴露于多氯联苯后，认知、注意力和记忆表现有所不同。西安尼斯顿、韦尔伯恩和霍布森市的人口提供了一个独特的机会，可以比较儿童在关键发育时期(12至15岁)暴露于多氯联苯的低暴露和高暴露的影响，因为该地区的暴露是有充分记录的。目前正在进行一项人口病例对照研究，该研究嵌套在一项涉及受影响社区6至8年级学生的横断面研究中。将对至少300名学生进行心理测试组件和血清铅、汞、镉以及多氯联苯，并对家长进行心理测试和多氯联苯水平。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. It is thought that children with evidence of high exposure to PCBs will perform more poorly on neurobehavioral and neurocognitive tests assessing executive function, memory and attention than low-exposed children from the same area. The relevance of the study is that the nature of the impact of PCB exposure on general cognitive abilities of children is somewhat unclear, although early studies have shown differences in cognition, attention and memory performance after exposure to PCBs in children. West Anniston, Wellborn and Hobson City populations represent a unique opportunity to compare the effects of low versus high PCB exposure in children at a critical developmental epoch (12 to 15 years of age), as exposure in the area is well documented. A population case control study nested within a cross-sectional study involving 6th through 8th grade students in the impacted communities is being conducted. A psychometric battery and serum lead, mercury, and cadmium, as well as PCBs will be performed on at least 300 students and psychometric testing and PCB levels performed on a parent.