Scanning Ocular Aberration Measurement (SAM) System

描述(由申请人提供)：1.项目总结：总体的、长期的目标是开发一种扫描眼睛像差测量(SAM)系统，以解决当前波前传感器的五个缺点。大多数或所有当前的系统：1)对于深度市场渗透来说太昂贵，2)不作为照明和调节的函数来监控光瞳大小和位置，3)不被设计成在获取检查时动态地改变调节需求，4)不允许根据所测量的像差结构的严重程度根据需要调整空间采样密度，以及5)用Zernike多项式来拟合波前像差，而不评估所产生的平滑误差的影响，并且不提供替代的拟合方法。为了达到弥补这5个缺点的目标，第二阶段的具体目标是：开发SAM硬件，开发SAM系统软件，开发SAM系统校准和测试项目，并集成这些SAM组件并进行系统级测试。SAM系统的商业应用包括临床测量，以支持定制视力矫正干预措施，如角膜激光手术、定制隐形眼镜和定制可植入镜片。该仪器还将能够为圆锥角膜或角膜移植等临床疑难病例提供更广泛的测量范围。实现了与健康相关，因为具有成本效益的仪器具有更好的实用性，能够处理更广泛的患者，从而加快了将经过验证的实验室技术转移到临床护理的速度。技术创新包括通过扫描微透镜阵列及其微孔阵列，根据需要进行可变空间采样，透明设计，以及作为环境照明和住宿功能的瞳孔位置监测。 2.相关性：SAM系统将提供一种成本效益高的仪器，能够测量比目前可用的更大范围的患者眼球像差。此外，当眼睛将焦点从远处转向近距离物体时，将提供动态测量这些像差的能力。

DESCRIPTION (provided by applicant): 1. Project summary: The broad, long-term objective is to develop a Scanning ocular Aberration Measurement (SAM) system that solves five shortcomings of current wavefront sensors. Most or all current systems: 1) are too expensive for deep market penetration, 2) do not monitor the pupil size and location as a function of illumination and accommodation, 3) are not designed to change the accommodative demand dynamically as exams are acquired, 4) do not allow spatial sampling density to be adjusted as required depending upon the severity of the aberration structure being measured, and 5) fit the wavefront aberration with a Zernike polynomial without evaluating the impact of the resulting smoothing error and do not provide an alternative fitting method. To achieve the goal of meeting these 5 shortcomings, the specific aims for Phase II will be to: develop the SAM hardware, develop the SAM system software, develop the SAM system calibration and test items, and integrate these SAM components and perform a system level test. The commercial applications for the SAM system include clinical measurements to support custom vision correction interventions such as cornea laser surgery, custom contact lens, and custom implantable lenses. The instrument will also be able to provide an extended range of measurements for clinically difficult cases such as keratoconus or cornea transplants. Health relatedness is achieved in that a cost effective instrument with improved utility capable of handling a broader range of patients quickens the transfer of proven laboratory technology to clinical care. Technological innovations include a variable spatial sampling dependent on need by scanning a micro-lenslet array and its micro-aperture array, a see-through design, and pupil location monitoring as a function of ambient illumination and accommodation. 2. Relevance: The SAM system will provide a cost effective instrument capable of measuring a broader range of patient's ocular aberrations than is currently available. In addition, the ability to measure these aberrations dynamically while the eye is changing focus from a distant to a near object will be provided.