Noninvasive Arterial Blood Gas Standard

描述（由申请人提供）：血气是迄今为止最常监测的化学参数。需要动脉氧（PaO2）来评估O2交换的效率。需要动脉二氧化碳（PaCO2）来评估通气效率，并且对于呼吸机管理最有用。然而，由于动脉血液采样在许多临床情况下是不实际的，因此需要不依赖于实验室测量作为参考的非侵入性血气监测。该提案介绍了一种新的概念，用于无创动脉血监测器，其将代谢校正应用于经皮二氧化碳测量。校正是从皮肤氧代谢数据获得的动脉和经皮氧测量的皮肤二氧化碳传感器的网站的差异。新原理结合了皮肤测量的自动校准和足够低的皮肤接触温度，以消除对测量设备的定期重新定位的需要。动脉血氧测量利用了应用于脉搏血氧测定的压力增强的新概念。由于动脉血液采样在许多临床情况下是不实际的，因此需要不依赖于实验室测量作为参考的非侵入性血气监测。该项目的总体目标是开发一种监测仪，可以提供准确可靠的血气数据，无创，而不需要额外的实验室测量作为参考。

DESCRIPTION (provided by applicant): Blood gases are by far the most frequently monitored chemical parameters. Arterial oxygen (PaO2) is needed to assess the efficiency of O2 exchange. Arterial carbon dioxide (PaCO2) is needed to assess efficiency of ventilation and is most useful for ventilator management. However, because arterial blood sampling is not practical in many clinical situations, there is a need for noninvasive blood gas monitoring which does not rely on laboratory measurements for references. This proposal introduces a new concept for a noninvasive arterial blood monitor which applies metabolic correction applied to transcutaneous carbon dioxide measurements. The correction is derived from cutaneous oxygen metabolism data obtained from the differences of arterial and transcutaneous oxygen measurements at the site of the cutaneous carbon dioxide sensor. The new principle incorporates automatic calibration of cutaneous measurements and a sufficiently low skin contact temperature, to eliminate the need for periodic relocation of the measuring device. The arterial oxygen measurement utilizes a new concept of pressure enhancement applied to pulse oximetry. Because arterial blood sampling is not practical in many clinical situations, there is a need for noninvasive blood gas monitoring which does not rely on laboratory measurements for references. The overall goal of the project is to develop a monitor which can provide accurate and reliable blood gas data, noninvasively, without need for additional laboratory measurements for reference.