Genomic and Proteomic Approaches to Complex Heart, Lung, Blood, & Sleep Disorders

描述(由申请人提供)： 大多数常见的心肺和血液疾病以及睡眠障碍都是由多个基因引起的复杂特征，并受到环境的强烈影响。遗传学、基因组学和蛋白质组学的最新进展极大地增加了我们对这些复杂疾病的原因，特别是如何进行治疗干预的理解迅速进步的机会。为了迅速将这些新工具送到研究实验室手中，我们建议在缅因州巴尔港的杰克逊实验室开设一个短期课程，名为“基因组和蛋白质组学方法治疗复杂的心、肺、血液和睡眠障碍”，夏季将在8-10天内提供。这门课程将以讲座、讨论、计算机实验室和研讨会的混合形式为基础，这门课程是在杰克逊实验室非常成功的课程“复杂心脏、肺、血液和睡眠障碍的遗传分析”的10年中开发的。本课程的目标将是(1)增加对基因组和蛋白质组方法在复杂疾病中的原理、方法和用途的理解，(2)欣赏和使用可用于研究复杂疾病的生物信息学资源，(3)有效地使用比较基因组学来理解复杂疾病，(4)提高使用基因组和蛋白质组方法进行研究设计的能力，以及(5)在课程参与者和教职员工之间发展促进跨学科研究的专业关系。目标受众将是开始其研究生涯的研究人员或希望在研究方向上做出重大改变的更资深的研究人员，其中临床研究人员占参与者的很大比例。缅因州大学的教育专家进行课程评估。我们当前课程的第一次长期跟踪显示，45%的参与者报告他们的研究目标发生了重大变化，57%的人报告了研究方法的重大变化，24%的人因为参加课程而发展了新的职业关系。与人类健康相关：心脏病、哮喘和慢性阻塞性肺病等肺部疾病、血液疾病和睡眠障碍是美国人口死亡和发病的主要原因。了解这些疾病的遗传基础对于开发新的安全疗法和更好的预防策略至关重要。像这样的短期课程对于培养一批高技能的年轻临床研究人员和研究人员至关重要，他们知道如何使用最新的工具来解决这些疾病的遗传基础。 (摘要结束)

DESCRIPTION (provided by applicant): Most common heart, lung, and blood diseases as well as sleep disorders are complex traits caused by multiple genes and strongly influenced by the environment. Recent advances in genetics, genomics and proteomics have greatly increased the opportunities for rapid advancement in our understanding of the causes of these complex diseases, particularly in how to intervene therapeutically. To rapidly place these new tools into the hands of research laboratories, we propose a short course, "Genomic and Proteomic Approaches to Complex Heart, Lung, Blood, & Sleep Disorders," to be offered during an 8-10 day period during the summer at The Jackson Laboratory in Bar Harbor, Maine. This course will be based on the mixed format of lectures, discussions, computer-laboratory, and workshops developed during 10 years of the highly successful course, "Genetic Analysis of Complex Heart, Lung, Blood, and Sleep Disorders," given at The Jackson Laboratory. The course goals will be to (1) increase understanding of the principles, methodologies, and uses of genomic and proteomic approaches in complex diseases, (2) appreciate and use the bioinformatics resources available for studying complex diseases, (3) use comparative genomics effectively in understanding complex disease, (4) increase the ability to develop study designs using genomic and proteomic approaches, and (5) develop professional relationships among course participants and faculty that promote interdisciplinary research efforts. The targeted audience will be investigators beginning their research career or more senior researchers who wish to make a significant change in research direction with clinical researchers comprising a significant proportion of the participants. Educational specialists at the University of Maine carry out course evaluations. The first long term follow-up of our current course showed that 45% of participants report a substantial change in the goals of their research, 57% report a substantial change in research methodology, and 24% developed new professional relationships as a result of participating in the course. Relevance to human health: Heart disease, lung diseases such as asthma and chronic obstructive pulmonary disease, blood diseases, and sleep disorders are major causes of mortality and morbidity in the American population. Understanding the genetic basis of these diseases is critical to developing new and safe therapies and better prevention strategies. Short courses such as these are critical to develop the cadre of highly skilled young clinical investigators and researchers that know how to use the latest tools in solving the genetic underpinnings of these disease. (End of Abstract)