WHOLE-BODY 7 TESLA MAGNETIC RESONANCE IMAGING SYSTEM

该子项目是利用由NIH/NCRR资助的共享仪器赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。列出的机构是用于资助的，不一定是研究者的机构。描述（由申请人提供）：自二十多年前MRI用于临床成像和研究以来，临床成像仪的磁场强度已从最初的0.15特斯拉（T）增加到目前的3 T，增加了20倍。早期认识到每单位扫描时间的图像质量主要由固有信噪比决定，这推动了商业3特斯拉系统的普及，为临床成像设定了新的性能标准。目前的趋势很可能会继续下去，因为下一代系统将在远高于3 T的磁场中运行。一些实验室的初步结果表明，在7- 9 T场强下的MRI和MRS具有很大的前景，可以提供在较低场强下无法获得的对人体结构、功能和生理学的洞察。美国和海外的几家领先机构要么已经拥有7 T全身系统，要么正在采购超高场扫描仪。然而，目前宾夕法尼亚大学没有7 T全身系统，我们也不知道邻近机构有计划委托这样的系统。在本提案中，我们申请资金用于在宾夕法尼亚大学医学中心放射科购买7 T全身MRI扫描仪。我们表明，拟议的系统将大大提高正在进行的研究在34个R 01，一个P41和三个程序项目赠款在四个中心：代谢磁共振研究和计算中心（MMRRCC），功能神经成像中心（CfN），分子成像中心（CEMI），和实验室结构核磁共振成像（LSNI）。这四个实验室的生物医学成像研究涵盖了广泛的应用和新方法开发，涉及基础和临床神经科学的功能性脑成像，神经退行性疾病和代谢紊乱的研究，癌症检测和治疗监测的分子成像，心血管疾病和组织灌注的新方法，以及关节和骨骼疾病（关节炎和骨质疏松症）。7 T系统将被集成到宾夕法尼亚大学的高级磁共振成像和光谱学中心（CAMRIS）。该资源将由一个执行委员会在目前的环境管理信息系统委员会的主持下管理。

This subproject is one of many research subprojects utilizing the resources provided by a Shared Instrumentation Grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the grant, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Since the inception of MRI for clinical imaging and research over two decades ago, the magnetic field strength of clinical imagers has increased 20-fold from 0.15 Tesla (T) initially to 3T currently. The early recognition that image quality per unit scan time is largely determined by the intrinsic signal-to-noise ratio has driven the diffusion of commercial 3 Tesla systems which have set a new performance standard for clinical imaging. It is likely that the current trend will continue in that the next generation systems will operate at fields considerably above 3T. Initial results from a few laboratories suggest MRI and MRS at field strengths of 7-9T to have great promise by providing insight into structure, function and physiology in humans not obtainable at lower fields. Several leading institutions in the US and overseas either already have 7T whole-body systems or are on their way to acquiring ultrahigh-field scanners in the near future. However, currently there is no 7T whole-body system at the University of Pennsylvania nor are we aware of plans by neighboring institutions of commissioning such a system. In this proposal we request funds for the acquisition of a 7T whole-body MRI scanner in the Department of Radiology at the University of Pennsylvania Medical Center. We show that the proposed system will substantially enhance ongoing research in 34 R01s, one P41 and three program project grants at four centers: the Metabolic Magnetic Resonance Research and Computing Center (MMRRCC), the Center for Functional Neuroimaging (CfN), the Center for Molecular imaging (CEMI), and the Laboratory for Structural NMR Imaging (LSNI). Biomedical imaging research in these four laboratories covers a wide range of applications and new methods development involving functional brain imaging for basic and clinical neuroscience, the study of neurodegenerative and metabolic disorders, molecular imaging for cancer detection and treatment monitoring, novel approaches to cardiovascular disease and tissue perfusion, and joint and bone disease (arthritis and osteoporosis). The 7T system will be integrated into the Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS) at the University of Pennsylvania. The resource will be run by an Executive Committee (EC) under the auspices of the current CAMRIS Committee.