PEDIATRIC MALIGNANCIES PROGRAM

儿科肿瘤项目的目标是通过基础和临床转化， 研究，癌症儿童的结果。儿科癌症在其形态、组织、组织和细胞方面是独特的。 起源和行为。它们提供了一个机会，使人们了解正常发育与 恶性肿瘤的畸变，遗传和环境的相互作用，以及 治疗本课题的主要目的是：（1）阐明大肠癌的分子发病机制， 通过识别重要的基因，蛋白质和途径来识别儿童癌症;（2）将这些信息转化为 改进诊断、分类、结果预测、治疗选择和流行病学 研究;（3）开发和进行临床I期、II期和III期试验，以提高生存率;（4）研究晚期 提高生存者的生活质量;（5）培训研究员、住院医师和学生 在儿科恶性肿瘤和指导初级教师与基础和临床研究培训奖。的 儿科肿瘤项目有来自10个不同部门的25名成员。主要研究 儿科恶性肿瘤项目的兴趣是儿科恶性肿瘤的分子和基因组研究 （特别是神经母细胞瘤、CMS肿瘤、白血病和视网膜母细胞瘤），发育治疗学， 神经母细胞瘤、脑肿瘤和白血病，以及儿童癌症的迟发效应和流行病学。的 通过与癌症中心项目的密切协同作用，如造血干细胞移植， 癌症，神经肿瘤学和烟草控制，以及与科学家的许多互动， 其他，基础科学计划，如癌症和免疫，细胞周期和信号，和癌症 遗传学，还有内核该计划有$4，444，595总同行审议的支持，为最后一个预算 年该方案有17%的方案内和40%的方案间出版物。 履约地点（组织、城市、州） UCSF综合癌症中心 加州弗朗西斯科 PHS 398/2590（2004年9月修订版）儿科恶性肿瘤项目

The goal of the Pediatric Malignancies Program is to improve, through basic and clinical translational research, the outcome for children with cancer. Pediatric cancers are unique in their morphology, tissues of origin and behavior. They provide an opportunity to understand the link between normal development and the aberrations of malignancy, the interactions of genetics and environment, and the late effects of treatment. The aims of the program are the following: (1) to elucidate the molecular pathogenesis of childhood cancer by identifying important genes, proteins and pathways; (2) to translate this information into improved diagnosis, classification, prediction of outcome, and treatment selection and epidemiological studies; (3) to develop and conduct clinical Phase I, II and III trials to improve survival; (4) to study the late effects of therapy and improve the quality of life for survivors; and (5) to train fellows, residents and students in pediatric malignancies and mentor junior faculty with basic and clinical research training awards. The Pediatric Malignancies Program has 25 members from 10 different departments. The main research interests of the Pediatric Malignancies Program are molecular and genomic studies of pediatric malignancies (particularly neuroblastoma, CMS tumors, leukemias and retinoblastoma), developmental therapeutics in neuroblastoma, brain tumors, and leukemia, and late effects and epidemiology of childhood cancer. The goals of the Program are enhanced by close synergy with Cancer Center Programs such as Hematopoietic Malignancies, Neurologic Oncology, and Tobacco Control, as well as many interactions with scientists in other, basic science Programs, such as Cancer and Immunity, Cell Cycling and Signaling, and Cancer Genetics, and with the Cores. The Program has $4,444,595 Total peer reviewed support for the last budget year. The Program has 17% intra-programmatic and 40% inter-programmatic publications. PERFORMANCE SITE(S) (organization, city, state) UCSF Comprehensive Cancer Center San Francisco, California PHS 398/2590 (Rev. 09/04) Page Pediatric Malignancies Program