Training Grant in Genetic and Immunology in Leishmaniasis

巴伊亚联邦大学免疫学处与美国和其他巴西机构合作，在利什曼病方面进行了20多年的研究项目，目的是：1）确定对利什曼病的免疫反应的特征; 2）将免疫反应与疾病的临床表现联系起来; 3）研究基因对疾病结果的影响; 4）确定新的治疗和控制措施形式;和5）鉴定干扰疾病结果的病原体组分。尽管免疫学服务得到了研究支持（包括TMRC，NIH赠款），但没有具体的支持来满足实施这些项目所需的培训需求。本提案将利用利什曼病研究中确定的需求，以实现以下具体目标：（1）在遗传学、疾病发病机理、临床调查和伦理学等领域创造培训机会，（2）向来自巴伊亚和巴西其他大学的其他调查人员传播培训。为了实现第一个目标，该计划强调与外国大学（康奈尔大学，爱荷华州大学，约翰霍普金斯，宾夕法尼亚大学，剑桥大学）合作，对博士后研究员进行长期培训（共5名），并对年轻和高级研究人员进行短期高级培训（共5名），以满足特定领域的专业知识的具体需求。为实现第二个目标，将利用国内的专门知识和资源以及受过高级培训的导师，在基础和临床免疫学、免疫疗法、分子和临床流行病学等领域以及在巴西导师培训后在上述新领域为本科生、研究生、年轻调查人员、医生和技术人员提供培训。

The Immunology Service of the Federal University of Bahia has ongoing research projects for more than 20 years in leishmaniasis in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune response to leishmania; 2) Correlating immunological response with clinical manifestations of the disease; 3) Studying genetic contributions to disease outcome, 4) Identifying new forms of therapy and control measures; and 5) Identifying pathogen components that interfere in disease outcome. Although the Immunology Service receives support for research (including a TMRC, NIH grant), there is no specific support for addressing training needs required to implement these projects. The present proposal will use needs identified in the studies of leishmaniasis to address the following specific aims: 1) To create training opportunities in areas such as genetics, disease pathogenesis, clinical investigation and ethics, 2) To disseminate training to other investigators from Bahia and other universities of Brazil. To address the first aim this program emphasizes collaboration with foreign universities (Cornell University, University of Iowa, Johns Hopkins, University of Pennsylvania, Cambridge University) for long-term training of post-doctoral fellows (total of 5) and short-term advanced training for young and senior investigators (total of 5) to address the specific needs in expertise within the specified areas. The second aim will be addressed by using the in-country expertise and resources and the advanced trained mentors to provide training for graduate, post-graduate students, young investigators, physicians and technicians in areas such as basic and clinical immunology, immunotherapy, molecular and clinical epidemiology, as well as in the new areas specified above after the training of the Brazilian mentors.