AIDS AND OPIATES: A MONKEY MODEL

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。药物滥用是艾滋病毒感染和艾滋病的一个突出危险因素。可靠的证据表明，阿片类药物对艾滋病没有影响，反而会加剧甚至抑制艾滋病的发展。在一项使用猴免疫缺陷病毒（SIV）感染的恒河猴模型的初步研究中，我们发现吗啡依赖减缓了艾滋病的进展。随后，我们启动了一项大型试验（20只恒河猴/组，吗啡与生理盐水），以进一步研究阿片类药物依赖与艾滋病进展之间的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. IV-drug abuse is a prominent risk factor for HIV infection and AIDS. Credible support can be found that opiates have no effect, exacerbate, or even inhibit AIDS progression. In a pilot study using the simian immunodeficiency virus (SIV) infected rhesus macaque model, we found that AIDS progression was slowed by morphine dependency. We have subsequently initiated a large trial (20 rhesus/group, morphine versus saline) to further investigate the relationship between opiate dependency and AIDS progression.