FLOW EFFECTS OF ENDOTHELIAL/TROPHOBLAST INTERACTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。目的:1。表征剪切应力对滋养细胞定向迁移的影响2。确定趋化因子和内皮粘附分子在剪应力介导的滋养细胞迁移中的作用。3. 确定剪切应力和滋养层-内皮细胞相互作用对诱导迁移滋养层表型的影响。4. 表征入侵猕猴子宫血管中CCR5、RANTES、蛋白聚糖和整合素的表达。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objectives: 1. Characterize the effect of shear stress on the directional migration of trophoblast cells 2. Determine the role of chemokines and endothelial adhesion molecules in shear stress-mediated trophoblast migration. 3. Determine the effect of shear stress and trophoblast-endothelial cell interaction on the induction of a migratory trophoblast phenotype. 4. Characterize the expression of CCR5, RANTES, proteoglycans, and integrins in invaded macaque uterine vessels.