SOMATOSENSORY CORTEX & THALAMUS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。目的：虽然5区一直被认为是一个后顶叶领域专门参与处理躯体输入，最近的证据，从我们的实验室在新世界和旧世界的猴子，以及其他实验室的工作，表明这个皮层区域也参与处理视觉输入，并与运动系统密切相关。越来越多的证据表明，5区可能是一个“中央计划者”，在有意达到和抓取过程中，将感觉位置转换为有意运动的运动坐标，并在感知身体的运动在额外的个人空间。本研究的目的是确定后顶叶5区在视觉引导和非视觉引导的到达和抓握、物体操作、双手的双侧协调以及跨大脑半球的信息传递中的作用。这项研究是首次尝试将联合收割机现代神经解剖学、电生理学和损伤技术结合起来，以确定单个皮质区域在产生复杂的手部使用中的作用。此外，这是少数几项利用电生理学和神经解剖学技术来研究皮质损伤后发生的长期皮质变化，然后进行行为训练的研究之一。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: While area 5 has been considered a posterior parietal field involved exclusively in processing somatic inputs, recent evidence from our laboratory in both New World and Old World monkeys, as well as work from other laboratories, indicate that this cortical area is also involved in processing visual inputs, and is closely associated with the motor system. Accumulating evidence indicates that area 5 may be a "central planner" critical for monitoring limb location during intended reaching and grasping, converting sensory locations into motor coordinates for intentional movement, and in perceiving the movements of the body in extra personal space. The goal of the present investigation is to determine the role of posterior parietal area 5 in visually guided and non-visually guided reaching and grasping, object manipulation, bilateral coordination of the hands, and information transfer across the cerebral hemispheres. This study represents one of the first attempts to combine modern neuroanatomical, electrophysiological, and lesioning techniques to determine the contribution of a single cortical field involved in generating sophisticated hand use. Further, it is one of the few studies that utilizes electrophysiological and neuroanatomical techniques to examine the long-term cortical changes that occur after cortical damage, followed by behavioral training.